磁共振成像2025，Vol.16Issue(3)：44-50,7.DOI:10.12015/issn.1674-8034.2025.03.007
影像组学对乳腺癌腋窝淋巴结转移诊断价值的Meta分析
Diagnostic value of radiomics for axillary lymph node metastasis in breast cancer:A Meta-analysis
摘要
Abstract
Objective:To evaluate the performance of radiomics in predicting axillary lymph node metastasis(ALNM)including sentinel lymph node metastasis(SLNM)in breast cancer by Meta analysis.Materials and Methods:A systematic search was conducted in the electronic databases PubMed,Embase,Web of Science,Cochrane Library,CNKI,and Wanfang database for relevant studies published between January 1,2018 and February 23,2024.The Quality Assessment of Diagnostic Accuracy Studies-2(QUADAS-2)was used to assess the quality of the included studies.The diagnostic odds ratio(DOR),sensitivity,specificity,and summary receiver operating characteristic(SROC)curve were calculated to evaluate the diagnostic value of imagingomics for ALNM,including SLNM,in breast cancer patients.Spearman correlation coefficients were calculated to assess threshold effects,and meta-regression and subgroup analyses were performed to explore possible causes of heterogeneity.Results:A total of 22 studies involving 4230 patients were included in the meta-analysis,summarizing the overall diagnostic accuracy of imaging-omics detection of ALNM,including SLNM:DOR was 34[95%confidence interval(CI):21 to 54];sensitivity 87%(95%CI:85%to 89%);specificity 76%(95%CI:75%to 78%);The area under the curve(AUC)of the SROC curve was 0.92,and Q* was 0.86;The positive likelihood ratio was 5.30(95%CI:3.70 to 7.60);The negative likelihood ratio was 0.17(95%CI:0.13 to 0.22).Meta-analysis showed that there was significant heterogeneity among the included studies,and there was no evidence of threshold effect.Conclusions:Our results suggest that imagingomics has good diagnostic performance in predicting ALNM,including SLNM,in breast cancer.Therefore,we recommend this method as a clinical method for preoperative identification of ALNM and SLNM.关键词
乳腺癌/腋窝淋巴结转移/影像组学/Meta分析/磁共振成像Key words
breast cancer/axillary lymph node metastasis/radiomics/Meta-analysis/magnetic resonance imaging分类
医药卫生引用本文复制引用
钱吉芳,朱大林,张旭霞,翟晓静,曹珊,孙碧霞..影像组学对乳腺癌腋窝淋巴结转移诊断价值的Meta分析[J].磁共振成像,2025,16(3):44-50,7.基金项目
Lanzhou Science and Technology Program Project(No.2022-3-16). 兰州市科技计划项目(编号:2022-3-16) （No.2022-3-16）
