摘要
Abstract
Objective:To explore the predictive value of radiomics models based on apparent diffusion coefficient(ADC)in evaluating the myometrial invasion depth of endometrial carcinoma(EC),providing a reliable evidence for clinicians to formulate treatment plans.Materials and Methods:Retrospective analysis of 155 patients with EC who underwent preoperative pelvic MR examination and were confirmed by pathology after operation from January 2016 to December 2023 in Beijing Luhe Hospital(superficial myometrial invasion=114,deep invasion=41),and randomly divided into training set(n=124)and validation set(n=31)in a 4∶1 ratio.The ITK-SNAP software was used to delineate the tumor regions layer by layer on the ADC maps,and the radiomics features were extracted,the extracted features were normalized.Pearson correlation coefficients(PCC)and least absolute shrinkage and selection operator(LASSO)were used to reduce features dimensionality,and the importance of the screened radiomics features was ranked according to the weight coefficient,the top 10 features were used to build radiomics models using three algorithms:logistic regression(LR),random forest(RF),and gradient boosting machine(GBM).The models were validated on the validation set.The performance of three radiomics models were evaluated by the receiver operating characteristic(ROC)curve,calibration curves,and decision curve analysis(DCA).The AUC values were compared using the DeLong test.Results:The AUC values of the LR,RF,and GBM models in predicting the invasion depth of endometrial carcinoma were 0.780(95%CI:0.762 to 0.804),0.860(95%CI:0.846 to 0.879),and 0.860(95%CI:0.843 to 0.877),respectively.The AUC values of the RF and GBM were the highest and equal.The DeLong test showed that there was a statistically significant difference in AUC values between LR,RF,and GBM models(P=0.017,0.023),while there was no statistically significant difference in AUC values between RF and GBM models(P=3.310).The calibration curve and DCA curve show that all three models have good fit and clinical practicality.Conclusions:The radiomics models based on ADC map have good value in predicting the invasion depth of EC.关键词
子宫内膜肿瘤/肌层浸润/磁共振成像/影像组学/机器学习/表观扩散系数Key words
endometrial carcinoma/myometrial invasion/magnetic resonance imaging/radiomics/machine learning/apparent diffusion coefficient分类
医药卫生
