全固态协同脉冲发生器的设计与研制OA北大核心

The irreversible electroporation technique has demonstrated remarkable efficacy in tumor treatment.Recent studies indicate that combining high-voltage nanosecond pulses with low-voltage microsecond pulses can significantly improve ablation effectiveness.To address this,this paper proposes a novel topology for a synergistic pulse generator,consisting of two Marx circuits utilizing insulated-gate bipolar transistors(IGBT)and metal-oxide-semiconductor field-effect transistors(MOSFETs)as main switching devices.By flexibly controlling these switches,the generator can produce a synergistic pulse sequence comprising high-voltage nanosecond pulses and low-voltage microsecond pulses.This study explores the generator's operating principle,circuit simulation,and prototype development.The resulting all-solid-state synergistic pulse generator features flexible and adjustable parameters,leveraging semiconductor switches for improved performance.Its functionality is evaluated using a 100 Ω resistance load,yielding the following pulse characteristics:nanosecond pulses with voltage amplitudes of 0 kV to 15 kV and pulse widths of 200 ns to 1 μs,and microsecond pulses with voltage amplitudes of 0 kV to 5 kV and pulse widths of 10 μs to 100 μs.These parameters meet the experimental requirements for synergistic pulsing in tumor ablation.