重庆大学学报2025，Vol.48Issue(3)：1-13,13.DOI:10.11835/j.issn.1000-582X.2024.213
全固态协同脉冲发生器的设计与研制
Design and development of a synergistic pulse generator based on all-solid-state switch devices
摘要
Abstract
The irreversible electroporation technique has demonstrated remarkable efficacy in tumor treatment.Recent studies indicate that combining high-voltage nanosecond pulses with low-voltage microsecond pulses can significantly improve ablation effectiveness.To address this,this paper proposes a novel topology for a synergistic pulse generator,consisting of two Marx circuits utilizing insulated-gate bipolar transistors(IGBT)and metal-oxide-semiconductor field-effect transistors(MOSFETs)as main switching devices.By flexibly controlling these switches,the generator can produce a synergistic pulse sequence comprising high-voltage nanosecond pulses and low-voltage microsecond pulses.This study explores the generator's operating principle,circuit simulation,and prototype development.The resulting all-solid-state synergistic pulse generator features flexible and adjustable parameters,leveraging semiconductor switches for improved performance.Its functionality is evaluated using a 100 Ω resistance load,yielding the following pulse characteristics:nanosecond pulses with voltage amplitudes of 0 kV to 15 kV and pulse widths of 200 ns to 1 μs,and microsecond pulses with voltage amplitudes of 0 kV to 5 kV and pulse widths of 10 μs to 100 μs.These parameters meet the experimental requirements for synergistic pulsing in tumor ablation.关键词
脉冲功率技术/Marx发生器/全固态/协同脉冲/肿瘤消融Key words
pulsed power technology/Marx generator/all-solid-state/synergistic pulse/tumor ablation分类
信息技术与安全科学引用本文复制引用
董守龙,朱黎明,岳亚琪,赵立胜,余亮,姚陈果..全固态协同脉冲发生器的设计与研制[J].重庆大学学报,2025,48(3):1-13,13.基金项目
国家自然科学基金青年科学基金资助项目(51807016,51907011) （51807016,51907011）
重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0932) （cstc2020jcyj-msxmX0932）
中央高校基本科研业务费(2020CDJYGSX001,2020CDJYGDQ008) （2020CDJYGSX001,2020CDJYGDQ008）
重庆市高等教育教学改革研究项目(213052) （213052）
重庆市研究生科研创新项目(CYB22016).Supported by National Natural Science Foundation of China Youth Science Fund Project(51807016,51907011),General Program of Chongqing Municipal Natural Science Foundation(cstc2020jcyj-msxmX0932),the Fundamental Research Funds for the Central Universities(2020CDJYGSX001,2020CDJYGDQ008),Chongqing Higher Education Teaching Reform Research Project(213052),and Chongqing Municipal Graduate Research and Innovation Project(CYB22016). （CYB22016）
