中国耳鼻咽喉头颈外科2025，Vol.32Issue(2)：94-99,6.DOI:10.16066/j.1672-7002.2025.02.007
不同颅内压状态下乙状窦沟骨板缺损性耳鸣的脑脊液流场及体积变化特征
Cerebrospinal fluid flow dynamics and volume changes in sigmoid sinus wall dehiscence-pulsatile tinnitus patients with different intracranial pressure
摘要
Abstract
OBJECTIVE To evaluate cerebrospinal fluid(CSF)flow dynamics and volume changes of pulsatile tinnitus(PT)patients caused by sigmoid sinus wall dehiscence(SSWD)with different intracranial pressure via MRI.METHODS Prospective enrolled 35 SSWD-PT patients with intracranial hypertension,25 SSWD-PT patients with normal intracranial pressure and 35 age-,sex-matched healthy controls.Demographic characteristics were recorded.Intracranial pressure was assessed by the index of transverse sinus stenosis(ITSS)and morphology changes.CSF flow dynamics were evaluated via phase-contrast magnetic resonance imaging(PC-MRI)and CSF volume were evaluated via three-dimensional T1-weighted turbo field echo(3D T1-TFE)sequence and ITK-SNAP software.Compared the differences of each index between three groups.RESULTS The mean flux and regurgitant fraction were significantly different among the three groups(P<0.05).The intracranial hypertension group presented significantly decreased mean flux(MF)and significantly increased regurgitant fraction(RF)compared to controls(P<0.017).There were no significant differences in MF and RF of normal intracranial pressure group compared with intracranial hypertension group and control group(P>0.017).There were no statistical differences in age,sex,body mass index,forward flow volume,backward flow volume,mean velocity,peak velocity,stroke volume and CSF volume(P>0.05).CONCLUSION SSW D-PT patients have abnormal changes in CSF,and those with increased intracranial pressure are more obvious.These changes may be associated with abnormal hemodynamics in the sigmoid sinus and the occurrence of PT.关键词
耳鸣/颅内压/磁共振成像/搏动性耳鸣/乙状窦沟骨板缺损/脑脊液/磁共振相位对比成像Key words
Tinnitus/Intracranial Pressure/Magnetic Resonance Imaging/pulsatile tinnitus/sigmoid sinus wall dehiscence/cerebrospinal fluid/phase-contrast magnetic resonance imaging引用本文复制引用
陈澜月,李薇,马晓博,曲晓霞,郑丹丹,刘兆会..不同颅内压状态下乙状窦沟骨板缺损性耳鸣的脑脊液流场及体积变化特征[J].中国耳鼻咽喉头颈外科,2025,32(2):94-99,6.基金项目
国家自然科学基金(82071882) （82071882）
北京市自然科学基金(7222029) （7222029）
