中国耳鼻咽喉头颈外科2025，Vol.32Issue(2)：116-120,5.DOI:10.16066/j.1672-7002.2025.02.011
血清过度磷酸化Tau蛋白和β淀粉样蛋白与阻塞性睡眠呼吸暂停综合征患者轻度认知功能障碍的相关性研究
Study on the correlation between serum hyperphosphorylated Tau protein,β-amyloid protein and mild cognitive impairment in patients with obstructive sleep apnea syndrome
摘要
Abstract
OBJECTIVE To investigate the correlation of serum P-Tau protein and β-amyloid protein expression levels with obstructive sleep apnea syndrome(OSAS)and mild cognitive impairment(MCI)patients,and their diagnostic value.METHODS From December 2020 to December 2023,120 patients with OSAS admitted to Third Hospital of Shijiazhuang were collected as the case group.According to the diagnostic criteria for MCI,patients were grouped into OSAS without MCI group(40 cases)and OSAS with MCI group(80 cases).ELISA method was applied to detect the levels of serum P-Tau protein and β-amyloid protein.Spearman method was applied to analyze the correlation between serum P-Tau protein,β-amyloid protein,and MCI.Multivariate logistic regression was applied to analyze the influencing factors of OSAS patients with MCI.ROC curve was applied to evaluate the diagnostic efficacy of serum P-Tau protein and β-amyloid protein in OSAS patients with MCI.RESULTS The Montreal Cognitive Assessment(MoCA)score in the OSAS with MCI group was obviously lower than that in the OSAS without MCI group(P<0.05).The expression levels of P-Tau protein and β-amyloid protein in the OSAS with MCI group were obviously higher than those in the OSAS without MCI group(P<0.05).The expression levels of serum P-Tau protein and β-amyloid protein in OSAS patients were negatively correlated with MoCA score(r=-0.346,-0.565,P<0.001).Serum P-Tau protein and β-amyloid protein were risk factors for OSAS with MCI(P<0.05).The AUC of the expression levels of serum P-Tau protein,β-amyloid protein,and their combination for OSAS with MCI was 0.751,0.848,and 0.928,respectively.The combined evaluation of the two showed better results(Zcombination-P-Tau protein=4.102,P<0.001;Zcombination-β amyloid protein=2.147,P=0.032).CONCLUSION The expression of serum P-Tau protein and β-amyloid protein is upregulated in OSAS patients with MCI,they are risk factors for the development of MCI in OSAS patients.The combined detection of the two has higher diagnostic efficacy.关键词
睡眠呼吸暂停,阻塞性/轻度认知功能障碍/血清P-Tau蛋白/β淀粉样蛋白/相关性Key words
Sleep Apnea,Obstructive/mild cognitive impairment/serum P-Tau protein/β-amyloid protein/correlation引用本文复制引用
冯丽,段毅,李娜,韩晓楠,底珊珊..血清过度磷酸化Tau蛋白和β淀粉样蛋白与阻塞性睡眠呼吸暂停综合征患者轻度认知功能障碍的相关性研究[J].中国耳鼻咽喉头颈外科,2025,32(2):116-120,5.基金项目
2025年河北省医学科学研究课题计划(20251107) （20251107）
