血清过度磷酸化Tau蛋白和β淀粉样蛋白与阻塞性睡眠呼吸暂停综合征患者轻度认知功能障碍的相关性研究OA
Study on the correlation between serum hyperphosphorylated Tau protein,β-amyloid protein and mild cognitive impairment in patients with obstructive sleep apnea syndrome
目的 探讨血清过度磷酸化Tau(P-Tau)蛋白和β淀粉样蛋白表达水平与阻塞性睡眠呼吸暂停综合征(OSAS)伴轻度认知功能障碍(mild cognitive impairment,MCI)患者的相关性及其诊断价值.方法 收集2020年12月～2023年12月石家庄市第三医院收治的OSAS患者120例为病例组.根据MCI诊断标准将患者分为OSAS无MCI组(40例)和OSAS伴MCI组(80例).采用ELISA法检测血清P-Tau蛋白和β淀粉样蛋白水平,Spearman法分析血清P-Tau蛋白和β淀粉样蛋白与MCI的相关性,采用多因素Logistic回归分析OSAS患者伴MCI的影响因素,受试者工作特征(ROC)曲线评估血清P-Tau蛋白和β淀粉样蛋白对OSAS患者伴MCI的诊断效能.结果 OSAS伴MCI组患者蒙特利尔认知评估表(MoCA)评分显著低于OSAS无MCI组(P<0.05);OSAS伴MCI组患者P-Tau蛋白和β淀粉样蛋白表达水平显著高于OSAS无MCI组(P<0.05);OSAS患者血清P-Tau蛋白和β淀粉样蛋白表达水平与MoCA评分呈负相关(r=-0.346、-0.565,P<0.001);血清P-Tau蛋白、β淀粉样蛋白是影响OSAS伴MCI的危险因素(P<0.05);血清P-Tau蛋白、β淀粉样蛋白表达水平以及二者联合评估OSAS伴MCI的AUC分别为0.751、0.848、0.928,二者联合评估效果更佳(Z二者联合-P-Tau蛋白=4.102,P<0.001;Z二者联合-β淀粉样蛋白=2.147,P=0.032).结论 OSAS伴MCI患者血清P-Tau蛋白和β淀粉样蛋白表达上调,是OSAS患者发生MCI的危险因素,二者联合检测具有更高的诊断效能.
OBJECTIVE To investigate the correlation of serum P-Tau protein and β-amyloid protein expression levels with obstructive sleep apnea syndrome(OSAS)and mild cognitive impairment(MCI)patients,and their diagnostic value.METHODS From December 2020 to December 2023,120 patients with OSAS admitted to Third Hospital of Shijiazhuang were collected as the case group.According to the diagnostic criteria for MCI,patients were grouped into OSAS without MCI group(40 cases)and OSAS with MCI group(80 cases).ELISA method was applied to detect the levels of serum P-Tau protein and β-amyloid protein.Spearman method was applied to analyze the correlation between serum P-Tau protein,β-amyloid protein,and MCI.Multivariate logistic regression was applied to analyze the influencing factors of OSAS patients with MCI.ROC curve was applied to evaluate the diagnostic efficacy of serum P-Tau protein and β-amyloid protein in OSAS patients with MCI.RESULTS The Montreal Cognitive Assessment(MoCA)score in the OSAS with MCI group was obviously lower than that in the OSAS without MCI group(P<0.05).The expression levels of P-Tau protein and β-amyloid protein in the OSAS with MCI group were obviously higher than those in the OSAS without MCI group(P<0.05).The expression levels of serum P-Tau protein and β-amyloid protein in OSAS patients were negatively correlated with MoCA score(r=-0.346,-0.565,P<0.001).Serum P-Tau protein and β-amyloid protein were risk factors for OSAS with MCI(P<0.05).The AUC of the expression levels of serum P-Tau protein,β-amyloid protein,and their combination for OSAS with MCI was 0.751,0.848,and 0.928,respectively.The combined evaluation of the two showed better results(Zcombination-P-Tau protein=4.102,P<0.001;Zcombination-β amyloid protein=2.147,P=0.032).CONCLUSION The expression of serum P-Tau protein and β-amyloid protein is upregulated in OSAS patients with MCI,they are risk factors for the development of MCI in OSAS patients.The combined detection of the two has higher diagnostic efficacy.
冯丽;段毅;李娜;韩晓楠;底珊珊
石家庄市第三医院 神经内二科,河北 石家庄 050000石家庄市第三医院 神经内二科,河北 石家庄 050000石家庄市第三医院 呼吸内科,河北 石家庄 050000石家庄市第三医院 呼吸内科,河北 石家庄 050000石家庄市第三医院 神经内二科,河北 石家庄 050000
睡眠呼吸暂停,阻塞性轻度认知功能障碍血清P-Tau蛋白β淀粉样蛋白相关性
Sleep Apnea,Obstructivemild cognitive impairmentserum P-Tau proteinβ-amyloid proteincorrelation
《中国耳鼻咽喉头颈外科》 2025 (2)
116-120,5
2025年河北省医学科学研究课题计划(20251107)
评论