广西医学2025，Vol.47Issue(2)：218-223,6.DOI:10.11675/j.issn.0253-4304.2025.02.10
弥漫大B细胞淋巴瘤患者METTL3和WTAP的表达水平及临床意义
Expression and clinical significance of METTL3 and WTAP in patients with diffuse large B-cell lymphoma
摘要
Abstract
Objective To investigate the expression and clinical significance of methyltransferase like 3(METTL3)and Wilms'tumor 1-associating protein(WTAP)in patients with diffuse large B-cell lymphoma(DLBCL).Methods A total of 84 newly diagnosed DLBCL patients were selected as the DLBCL group,and 50 patients with reactive lymph node hyperplasia(RLH)as the RLH group.Expressions of METTL3 and WTAP were compared between patients of the two groups,and between DLBCL patients with different clinical characteristics.The correlation between METTL3 expression and WTAP expression was analyzed in DLBCL patients.The short-term chemotherapy efficacy was compared between DLBCL patients with different expressions of METTL3 and WTAP.The Kaplan-Meier curve was drawn to analyze the relation of METTL3 and WTAP expressions with prognosis of DLBCL patients.The COX proportional risk model was adopted to analyze the factors for affecting prognosis of DLBCL patients.Results The positive rates of METTL3 and WTAP were higher in the DLBCL group than in the RLH group(P<0.05).METTL3 expression positively correlated with WTAP expression in DLBCL patients(P<0.05).DLBCL patients with Ann Arbor clinical staging in Ⅲ-Ⅳ,Hans classification in non-GCB type obtained higher positive rates of METTL3 and WTAP as compared with DLBCL patients with Ann Arbor clinical staging in Ⅰ-Ⅱ,Hans classification in GCB type(P<0.05).The objective remission rate and 3-year survival rate of patients with METTL3 and WTAP positive were lower as compared with patients with METTL3 and WTAP negative,respectively(P<0.05).Ann Arbor clinical staging in Ⅲ-Ⅳ,METTL3 positive,WTAP positive were the risk factors for affecting the prognosis of DLBCL patients(P<0.05).Conclusion Expressions of METTL3 and WTAP are elevated in DLBCL patients,their expressions are related to Ann Arbor clinical staging and Hans classification of DLBCL patients.Patients with high METTL3 and WTAP expressions obtain a relatively low 3-year survival rate,and both two as above are the influencing factors for DLBCL prognosis.关键词
弥漫大B细胞淋巴瘤/甲基化转移酶3/Wilms肿瘤抑制因子/预后/影响因素Key words
Diffuse large B-cell lymphoma/Methyltransferase like 3/Wilms'tumor 1-associating protein/Prognosis/Influencing factors分类
临床医学引用本文复制引用
朱丽,丛智荣,江棋..弥漫大B细胞淋巴瘤患者METTL3和WTAP的表达水平及临床意义[J].广西医学,2025,47(2):218-223,6.基金项目
江苏省卫生健康委员会医学科研立项项目(S2020044) （S2020044）
