广西中医药大学学报2025，Vol.28Issue(2)：5-9,5.
柔肝化纤颗粒治疗肝硬化门脉高压的疗效及对患者肝静脉压力梯度的影响
Efficacy of Rougan Huaxian Granules in the Treatment of Cirrhotic Portal Hypertension and Its Impact on Hepatic Venous Pressure Gradient
摘要
Abstract
[Objective]To observe the efficacy of Rougan Huaxian granules combined with western medicine in the treatment of cirrhotic portal hypertension and its impact on clinical hepatic venous pressure gradient(HVPG).[Methods]Sixty-four patients with cirrhotic portal hypertension were randomly divided into the control group and the treatment group,with 32 in each.The control group received conventional liver protection and symptomatic treatment with western medicine,while the treatment group received additional oral administration of Rougan Huaxian granules on the basis of the control group's treatment.After 6 months of treatment,the clinical efficacy,as well as changes in Traditional Chinese Medicine(TCM)syndrome scores,liver function,liver fibrosis indicators[hyaluronic acid(HA),laminin(LN),type Ⅲ precollagen(PCⅢ),type Ⅳ collagen(Ⅳ-C)],and hepatic venous pressure gradient[free hepatic venous pressure(FHVP),wedged hepatic venous pressure(WHVP),and HVPG]were observed in both groups.[Results]The clinical total effective rate was 93.75%in the treatment group and 63.63%in the control group,indicating that the treatment group had superior efficacy(P<0.05).After treatment,the TCM syndrome scores,the levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBIL),HA,LN,PCⅢ,Ⅳ-C,HVPG and WHVP in both groups decreased compared with those before treatment(P<0.05).And the decrease was more significant in the treatment group than that in the control group(P<0.05).The albumin(ALB)lev-els increased in both groups after treatment compared with those before treatment.And the increase was more signifi-cant in the treatment group than that in the control group(P<0.05).[Conclusion]Rougan Huaxian granules can signif-icantly improve liver function,effectively alleviate clinical symptoms caused by portal hypertension,inhibit liver fi-brosis,and reduce HVPG in patients with cirrhotic portal hypertension.It has a potential role in preventing variceal bleeding.关键词
肝硬化门脉高压/柔肝化纤颗粒/肝静脉压力梯度/中西医结合疗法Key words
cirrhotic portal hypertension/Rougan Huaxian granules/hepatic venous pressure gradient/integrat-ed traditional Chinese and western medicine therapy分类
医药卫生引用本文复制引用
何坚科,张文富,吴姗姗,王振常..柔肝化纤颗粒治疗肝硬化门脉高压的疗效及对患者肝静脉压力梯度的影响[J].广西中医药大学学报,2025,28(2):5-9,5.基金项目
广西中医药适宜技术开发与推广项目(编号:GZSY21-45) （编号:GZSY21-45）
广西自然科学基金项目(编号:2020GXNSFDA297021) （编号:2020GXNSFDA297021）
