广西医学2025，Vol.47Issue(2)：170-176,7.DOI:10.11675/j.issn.0253-4304.2025.02.03
儿童慢性肾脏病贫血的发病机制及治疗进展
Pathogenesis and treatment progress of anemia in children with chronic kidney disease
摘要
Abstract
Anemia is a common complication of chronic kidney disease(CKD)in children.It often occurs in stage 3 of CKD and is often manifested as fatigue and discomfort,loss of appetite,and poor exercise tolerance,etc.In severe cases,there will be dizziness,dyspnea,and cardiovascular related manifestations,which seriously affect the growth and development of children and the quality of their life.Anemia is not only a clinical manifestation of CKD,but also an important marker of disease progression,which needs to be paid enough attention.Current studies have reveled that the etiology of anemia in children with CKD is complex,involving a variety of factors such as erythropoietin(EPO)resistance or relative insufficient production,insufficient raw materials for erythropoiesis,and effects of cytokines inhibition.This paper reviews the pathogenesis and treatment progress of anemia in children with CKD,especially the supplement of iron deficiency,the application of EPO,and the use of novel therapeutic drugs,aiming at better addressing the challenges posed by anemia in children with CKD.关键词
慢性肾脏病/贫血/儿童/发病机制/治疗进展/综述Key words
Chronic kidney disease/Anemia/Children/Pathogenesis/Treatment progress/Review分类
医药卫生引用本文复制引用
陈秀萍,雷凤英..儿童慢性肾脏病贫血的发病机制及治疗进展[J].广西医学,2025,47(2):170-176,7.基金项目
广西儿科疾病临床医学研究中心基金资助项目(桂科AD22035219) （桂科AD22035219）
广西壮族自治区卫生健康委自筹经费科研课题(Z-A20240552) （Z-A20240552）
