皮肤性病诊疗学杂志2025，Vol.32Issue(3)：180-184,5.DOI:10.3969/j.issn.1674-8468.2025.03.004
阿奇霉素与多西环素治疗直肠及尿道沙眼衣原体感染的疗效对比
Comparison of the efficacy of azithromycin and doxycycline for Chlamydia trachomatis in-fection in the rectum and urinary tract
摘要
Abstract
Objective The purpose of this study was to compare the efficacy of azithromycin and doxycycline in the treatment of Chlamydia trachomatis infection in the rectum and urinary tract.Methods From November 2019 to April 2023,male volunteers who had sex with men(MSM)were recruited for Chlamydia trachomatis testing of the rectum and urinary tract.Patients diagnosed with Chlamydia trachomatis infection were treated orally with either azithromycin or dox-ycycline.Azithromycin was given orally at a dose of 1 g on the first day,and 0.5 g on the second and third days,or 100 mg of oral doxycycline was given twice daily,for 7 consecutive days.Nu-cleic acid testing for Chlamydia trachomatis was conducted to compare the microbial clearance rates three weeks after the therapy.Results A total of 1 596 MSM were recruited,including 125 cases of Chlamydia trachomatis rectal infection and 59 cases of urethral infection.After excluding individuals who did not undergo follow-up examinations and those having high-risk behaviors dur-ing the study period,152 cases of Chlamydia trachomatis infection were included in this study.Azithromycin was given to 97 cases,including 72 cases of rectal infection and 25 cases of urethral infection.Doxycycline was given to 55 cases,including 30 cases of rectal infection and 25 cases of urethral infection.Three weeks after the therapy,all cases in the azithromycin group were negative for Chlamydia trachomatis,while in the doxycycline group,5 cases of rectal infection and 2 cases of urethral infection were positive for Chlamydia trachomatis,resulting in a microbial clearance rate of 87.27％(48/55).The total microbial clearance rate in the azithromycin group was signifi-cantly higher than that in the doxycycline group(x2=12.94,P＜0.001).Following azithromy-cin therapy,all Chlamydia trachomatis positive cases in the doxycycline group became negative.Conclusions Azithromycin at a dose of 2 g can be used as a first-line treatment option for simple Chlamydia trachomatis infection in the rectum and urinary tract.关键词
沙眼衣原体/直肠感染/尿道感染/阿奇霉素/多西环素Key words
Chlamydia trachomatis/rectum infection/urinary tract infection/azithromy-cin/doxycycline引用本文复制引用
张晓辉,赵培祯,杨立刚,廖玉英,林晓昕,王柳苑,陈惠茹,吴育娇,谢冬梅,柯吴坚,李秀雯..阿奇霉素与多西环素治疗直肠及尿道沙眼衣原体感染的疗效对比[J].皮肤性病诊疗学杂志,2025,32(3):180-184,5.基金项目
广州市健康医疗协同创新重大专项(201704020219) （201704020219）
