皮肤性病诊疗学杂志2025，Vol.32Issue(3)：190-195,6.DOI:10.3969/j.issn.1674-8468.2025.03.006
氨甲环酸联合窄谱强脉冲光治疗黄褐斑的临床研究
Clinical study on the efficacy of tranexamic acid combined with narrowband intense pulsed light for the treatment of melasma
薛呈毅 1郭开忠 1张国成 2陈军3
作者信息
- 1. 高邮市人民医院皮肤科,江苏 高邮 225600
- 2. 中国医学科学院皮肤病医院
- 3. 南京医科大学第四附属医院皮肤科,江苏 南京 210000
- 折叠
摘要
Abstract
Objective To investigate the efficacy and patients'satisfaction of combing narrow-band intense pulsed light(DPL)with tranexamic acid for the treatment of facial melasma.Meth-ods Ninety melasma patients treated at Gaoyou People's Hospital between November 2022 and August 2024 were randomly divided into three groups(30 patients per group).The medication group received oral tranexamic acid tablets(0.25 g twice daily for 6 months),while the DPL group underwent DPL treatment once per month for 4 sessions.The combination group received both interventions following the same protocols as the other two groups.The melasma area and se-verity index(MASI)scores were compared before and after the treatment.The efficacy and pa-tients'satisfaction were evaluated after the treatment.Adverse reactions and recurrence rates were also monitored.Results After the treatment,the combination group achieved a greater reduction in MASI scores than the other two groups(62.20±19.14％vs.48.10±22.18％in the DPL group and 45.32±20.74％in the medication group,P＜0.05).Moreover,both total effective rate and patients'satisfaction scores were higher in the combination group than the other groups(80.00％vs.53.33％in the DPL group and 50.00％in medication group,P＜0.05).No sig-nificant adverse reactions were observed across groups.At six-month follow-up,no recurrence was observed in the combination group,while 2 cases were reported in the DPL group and 1 case in the medication group.Conclusion The combination of DPL and tranexamic acid represents a safe and effective approach for the management of melasma.关键词
黄褐斑/氨甲环酸/窄谱强脉冲光Key words
melasma/tranexamic acid/narrowband intense pulsed light引用本文复制引用
薛呈毅,郭开忠,张国成,陈军..氨甲环酸联合窄谱强脉冲光治疗黄褐斑的临床研究[J].皮肤性病诊疗学杂志,2025,32(3):190-195,6.
