皮肤性病诊疗学杂志2025，Vol.32Issue(3)：206-210,5.DOI:10.3969/j.issn.1674-8468.2025.03.008
环孢菌素A联合糖皮质激素成功治疗反复发作的药物超敏反应综合征1例
Successful treatment of a case of recurrent drug reaction syndrome with a combination of cyclosporine and glucocorticoids
包凌云 1刘雯敏 2聂小娟 2李圆圆 2宋亚丽3
作者信息
- 1. 山东大学齐鲁医学院,山东 济南 250012||山东第一医科大学附属省立医院,山东 济南 250021
- 2. 山东第一医科大学附属省立医院,山东 济南 250021
- 3. 山东大学齐鲁医学院,山东 济南 250012||山东大学附属公共卫生临床中心,山东 济南 250102
- 折叠
摘要
Abstract
A case of recurrent drug reaction with eosinophilia and systemic symptoms success-fully treated with cyclosporine combined with glucocorticoids is reported.A 36-year-old female presented with an one-month history of recurrent,itchy erythemas and papules covering her entire body.Dermatological examination revealed a swollen face,and millet-sized macules and papules all over the body.Enlarged lymph nodes were palpated bilaterally behind the ears,on the sides of the neck,in the axillae,and in the inguinal areas.The results of laboratory tests at admission were as the follows:leukocyte count,11.36 × 109/L;absolute eosinophil count(EO),0.66 × 109/L;glutamic oxaloacetic transaminase,181 U/L;glutamic pyruvic transaminase,370 U/L;IgE count,21 500 IU/mL;positive for both HHV-6-DNA and CMV-DNA,and an EBV-DNA count,1.00 × 105 copies/mL.The diagnosis was drug reaction with eosinophilia and systemic symptoms(DRESS).The patient was treated with cyclosporin A and glucocorticoids,supplemen-ted with antiviral therapy.The patient's generalized rashes gradually subsided after the treatment,leaving a few hyperpigmented spots.The patient was followed up for more than 3 months without recurrence.关键词
药物超敏反应综合征/环孢菌素A/药物特异性T细胞Key words
drug reaction with eosinophilia and systemic symptoms/cyclosporine/drug-specific T-cells引用本文复制引用
包凌云,刘雯敏,聂小娟,李圆圆,宋亚丽..环孢菌素A联合糖皮质激素成功治疗反复发作的药物超敏反应综合征1例[J].皮肤性病诊疗学杂志,2025,32(3):206-210,5.
