皮肤性病诊疗学杂志2025，Vol.32Issue(3)：215-221,7.DOI:10.3969/j.issn.1674-8468.2025.03.010
梅毒螺旋体黏附蛋白与宿主细胞间的作用研究进展
Research progress on the interactions between Treponema pallidum adhesion proteins and host cells
摘要
Abstract
Treponema pallidum(Tp)has an outer membrane that encircles the periplasmic space,the peptidoglycan,cytoplasmic membrane,and protoplasmic components.The low abun-dance of lipopolysaccharides and transmembrane proteins enable it to conceal itself and to exert ro-bust capabilities for tissue invasion and immune escape.Adhesion-mediated colonization plays a significant role in the pathogenesis of syphilis caused by Tp.In vitro studies have shown that Tp can adhere to cells of humans and other mammals,with a preference for interacting with specific molecules on certain cell surfaces,thereby influencing the invasion,pathogenicity and immune es-cape of Tp.This review summarizes how adhesion proteins of Tp interact with various host cells to trigger invasion and infection,and overviews their role in syphilis pathogenesis,aiming to offer significant insights for research into etiology,vaccine development,and the discovery of novel therapeutic agents for syphilis.关键词
梅毒螺旋体/黏附蛋白/宿主细胞Key words
Treponema pallidum/adhesin protein/host cells引用本文复制引用
黄佳林,郑举敦..梅毒螺旋体黏附蛋白与宿主细胞间的作用研究进展[J].皮肤性病诊疗学杂志,2025,32(3):215-221,7.基金项目
国家自然科学基金(82102444) （82102444）
广东省普通高校重点领域专项项目(2023ZDZX202) （2023ZDZX202）
广州市基础与应用基础研究专题青年博士"启航"项目(SL2024A04J01463) （SL2024A04J01463）
