生命科学仪器2025，Vol.23Issue(2)：7-9,3.DOI:10.11967/2025230403
肺癌自身抗体在早期肺癌诊断中的准确性分析
Accuracy Analysis of Lung Cancer Autoantibodies in the Diagnosis of Early Lung Cancer
刘煜恒 1陈赟翔 1闫若辰1
作者信息
- 1. 天津市胸科医院检验科,天津 300222
- 折叠
摘要
Abstract
Objective:To explore the clinical value of lung cancer autoantibody diagnosis in patients with early lung cancer.Methods:Sixty patients with early lung cancer admitted to Tianjin Chest Hospital from January 2022 to June 2023 were selected as the observation group.60 patients with benign lung diseases were selected as the control group.Enzyme-linked immunosorbent assay(ELISA)was used to detect the autoantibodies of lung cancer in two groups,and the diagnostic value was analyzed.Results:The concentrations of GAGE7、GBU4-5 and CAGE in the observa-tion group were higher than those in the control group,P<0.05.The expression levels of other autoantibodies in the two groups were compared,P>0.05.The positive detection rates of SOX2、GAGE7、GBU4-5 and GAGE in the ob-servation group were higher than those in the control group,P<0.05.The positive rate of combined diagnosis in ob-servation group was higher than that in control group,P<0.05.The sensitivity of single diagnosis is low and the spe-cificity is high,and the AUC of GBU 4-5 is 0.662.The specificity of combined diagnosis decreased,and the AUC of combined diagnosis was 0.814,which was higher than that of single diagnosis.Conclusion:Single autoantibody has low sensitivity and high specificity in the diagnosis of patients with early lung cancer,while combined diagnosis has high di-agnostic efficiency and high clinical application value.关键词
早期肺癌/自身抗体/检测准确性/阳性检出率Key words
Early-stage lung cancer/Autoantibody/Accuracy/Positive detection rate分类
医药卫生引用本文复制引用
刘煜恒,陈赟翔,闫若辰..肺癌自身抗体在早期肺癌诊断中的准确性分析[J].生命科学仪器,2025,23(2):7-9,3.
