皮肤性病诊疗学杂志2025，Vol.32Issue(3)：176-179,4.DOI:10.3969/j.issn.1674-8468.2025.03.003
奥马珠单抗治疗可升高慢性自发性荨麻疹患者外周血中维生素D的水平
Omalizumab treatment can increase the serum levels of vitamin D in patients with chronic spontaneous urticaria
摘要
Abstract
Objective To investigate the effect of omalizumab treatment on circulating levels of 25(OH)D in patients with chronic spontaneous urticaria(CSU).Methods Thirty-six patients with CSU were treated with 300 mg of omalizumab once every 4 weeks for 3 months.Spearman rank correlation analysis was performed to determine the correlation between UAS7 and 25(OH)D levels before the treatment.UAS7 scores and 25(OH)D levels in patients were compared before and after the treatment,and with those in the controls(36 healthy subjects).Results UAS7 was negatively correlated with 25(OH)D levels in peripheral blood of CSU patients before the treat-ment(r=-0.60,P=0.001).The 25(OH)D levels were significantly higher after the treatment than before the treatment[(27.91±7.37)ng/mL vs.(18.74±6.90)ng/mL,t=5.45,P＜0.001].However,both of them were lower than the normal controls[(35.42±7.83)ng/mL],t=4.19,9.59,respectively,both P＜0.001.After the treatment,UAS7 was significantly lower than that before the treatment[(2.00±3.00)vs.(22.03±5.05),U=20.48,P＜0.001].Conclusions Omalizumab treatment can increase the serum 25(OH)D levels in patients with chronic spontaneous urticaria.25(OH)D may play a protective role in the pathogenesis of chronic spontaneous urticaria.关键词
慢性自发性荨麻疹/奥马珠单抗/25(OH)DKey words
chronic spontaneous urticaria/omalizumab/25(OH)D引用本文复制引用
孟珍,唐亚平..奥马珠单抗治疗可升高慢性自发性荨麻疹患者外周血中维生素D的水平[J].皮肤性病诊疗学杂志,2025,32(3):176-179,4.基金项目
市校(院)企联合资助项目(SL2024A03J01059) （院）
