生物骨科材料与临床研究2025，Vol.22Issue(2)：1-6,6.DOI:10.3969/j.issn.1672-5972.2025.02.001
脉冲射频与富血小板血浆治疗早中期膝骨关节炎的疗效及对血清标志物的影响
Efficacy of pulsed radiofrequency and platelet-rich plasma therapy in early to mid-stage knee osteoarthritis and its impact on serum biomarkers
摘要
Abstract
Objective To observe the therapeutic effects of intra-articular pulsed radiofrequency(PRF)and platelet-rich plasma(PRP)injections in early to mid-stage knee osteoarthritis(OA)and their influence on relevant serum biomarkers,and to explore the underlying mechanisms of these two treatment modalities.Methods A retrospective study was conducted on 76 patients with early to mid-stage knee OA treated at our department from August 2019 to January 2022.Patients were divided into the PRF group(n=40)and the PRP group(n=36)based on the different treatment methods.Visual analog scale(VAS),Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC),and Short Form 36 Health Survey(SF-36)scores were assessed before treatment,and at 1,3,and 6 months after treatment to evaluate clinical efficacy.Serum levels of interleukin-6(IL-6),interleukin-1β(IL-1β),transforming growth factor-β1(TGF-β1),cartilage oligomeric matrix protein(COMP),type Ⅱ collagen and bone morphogenetic protein-2(BMP-2)were measured in both groups before and 3 months after treatment to explore possible mechanisms of action.Results The follow-up period was 6-9 months,with an average of(7.12±2.09)months.At 1,3,and 6 months after treatment,VAS and WOMAC scores significantly improved in both groups compared to baseline(P<0.05).At 1 and 3 months after treatment,the improvement in VAS score was more significant in the PRF group compared to the PRP group,with statistically significant differences between the two groups(P<0.05).At 3 months after treatment,significant changes in IL-6,IL-1β,TGF-β1,and BMP-2 levels were observed in the PRF group compared to baseline,and in the PRP group,significant changes in IL-6,IL-1β,TGF-β1,COMP,type Ⅱ collagen,and BMP-2 levels were observed in the PRP group compared to baseline,with statistically significant between-group differences(P<0.05).Moreover,the changes in COMP,type Ⅱ collagen,and BMP-2 levels were more significant in the PRP group compared to the PRF group,with statistically significant differences between the two groups(P<0.05).Conclusion Both PRF and PRP are effective in improving pain and joint function in patients with early to mid-stage knee OA,with PRF demonstrating more significant short-term analgesic effects.The mechanisms of action of these two treatments may be associated with the inhibition of joint inflammation,and PRP may possess certain chondral repair potential.关键词
脉冲射频/富血小板血浆/膝关节骨关节炎/血清标志物Key words
Pulsed radiofrequency/Platelet-rich plasma/Knee osteoarthritis/Serum biomarkers分类
临床医学引用本文复制引用
李培金,韩倩,王威,唐园,左昌俊,叶劲,李照文..脉冲射频与富血小板血浆治疗早中期膝骨关节炎的疗效及对血清标志物的影响[J].生物骨科材料与临床研究,2025,22(2):1-6,6.基金项目
武汉市卫生健康科研资助项目(WX21Q10) （WX21Q10）
