日用化学品科学2025，Vol.48Issue(4)：31-36,6.DOI:10.3969/j.issn.1006-7264.2025.04.007
橄榄油发酵滤液工艺优化及其体外功效研究
Study on process optimization and in vitro efficacy of olive oil fermentation filtrate
蔡红丽 1何益飞 1杨志坚 1潘翠霞2
作者信息
- 1. 深圳市仙迪化妆品股份有限公司,广东 深圳 518100
- 2. 广州市仙迪生物科技有限公司,广东 广州 510900
- 折叠
摘要
Abstract
The olive oil fermentation filtrate was prepared by microbial fermentation technology,and the fermentation process was optimized by an orthogonal test to screen out the optimal fermentation conditions.At the same time,the effect of olive oil fermentation filtrate on promoting the secretion of type I collagen(COL-I)and type VII collagen(COL-VII)from fibroblasts(HFF-1),on inhibiting the secretion of alpha tumor necrosis factor(TNF-α)and interleukin-6(IL-6)from lipopolysaccharide-induced macrophages(RAW264.7),and on inhibiting the induction of reactive oxygen species(ROS)production by immortalized human keratinocytes(HaCaT)were investigated in vitro.The results showed that the optimal fermentation conditions of olive oil fermentation filtrate were:3%inoculum,2%inducer addition,and 48 h fermentation time.The olive oil fermentation filtrate can significantly promote the synthesis of COL-I and COL-VII,can significantly inhibit the content of inflammatory factors TNF-α and IL-6 as well as the content of ROS,and has multiple effects of firming,anti-wrinkles,soothing and antioxidant,which can provide scientific and effective data support for the development of raw materials for cosmetic products.关键词
橄榄油/发酵/化妆品/体外功效Key words
olive oil/fermentation/cosmetic/in vitro efficacy分类
化学工程引用本文复制引用
蔡红丽,何益飞,杨志坚,潘翠霞..橄榄油发酵滤液工艺优化及其体外功效研究[J].日用化学品科学,2025,48(4):31-36,6.
