日用化学品科学2025，Vol.48Issue(4)：43-49,7.DOI:10.3969/j.issn.1006-7264.2025.04.009
新型早C晚A组合精华液协同抗衰功效研究
Synergistic anti-aging effects of novel morning C and night A combination serums
宋雅玲 1沈轶昕 1徐慧琳 1曹正 1黄洁芳 1叶迎 1宣灵灵 1王菁1
作者信息
- 1. 珀莱雅化妆品股份有限公司,浙江 杭州 310023
- 折叠
摘要
Abstract
This study evaluates the synergistic anti-aging effects of combining Serum C,enriched with ergothioneine,Lavandula angustifolia(Lavender)flower extract,and dipeptide-4,and Serum A,containing retinol and collagen peptide,on skin aging.An in vitro model of skin aging was established using UV irradiation,followed by the application of Serum C in the morning and Serum A at night.Immunofluorescence staining was used to assess extracellular matrix(ECM)components,oxidative stress markers,and carbonylation levels.Results showed that the combination of Serums C and A significantly increased the thickness of the viable epidermal layer and the density of dermal fibroblasts,while enhancing the expression of ECM components(Collagen I,Elastin,and Fibrillin-1).Serum A potentiated the effect of Serum C on the expression of Nrf2 and its associated antioxidant proteins(SOD,HO-1,and GSH-Px1),and inhibited carbonylation.Serum C significantly enhanced the ability of Serum A to promote TGF-β1 expression.Additionally,the combination treatment significantly increased the expression of barrier protein LOR,aiding in skin barrier repair.The combined morning use of Serum C and night use of Serum A effectively improved skin aging,demonstrating a synergistic effect.关键词
麦角硫因/薰衣草花提取物/二肽-4/视黄醇/胶原肽/皮肤衰老Key words
ergothioneine/Lavandula angustifolia(Lavender)flower extract/dipeptide-4/retinol/collagen peptide/skin aging分类
化学工程引用本文复制引用
宋雅玲,沈轶昕,徐慧琳,曹正,黄洁芳,叶迎,宣灵灵,王菁..新型早C晚A组合精华液协同抗衰功效研究[J].日用化学品科学,2025,48(4):43-49,7.
