中国当代儿科杂志2025，Vol.27Issue(4)：480-486,7.DOI:10.7499/j.issn.1008-8830.2411142
孤独症谱系障碍中性别差异的研究进展
Advances in research on gender differences in autism spectrum disorders
摘要
Abstract
Autism spectrum disorder(ASD)is a neurodevelopmental disorder characterized by social impairments,repetitive behaviors,and restricted interests.Studies have shown that it is more prevalent in males than females.Although this issue has attracted academic attention since the 20th century,the specific mechanisms underlying the gender differences in ASD remain unclear.This paper reviews the impact of gender differences in ASD,focusing on the female protective effect,DNA methylation,hormone levels,and clinical manifestations.It also discusses corresponding treatment options,particularly suggesting improvements in the diagnostic process,which is often overlooked,in order to provide valuable references for the clinical diagnosis and treatment of ASD.关键词
孤独症谱系障碍/性别差异/女性保护效应/遗传学/激素水平/表观遗传学/DNA甲基化Key words
Autism spectrum disorder/Gender difference/Female protective effect/Genetics/Hormone level/Epigenetics/DNA methylation引用本文复制引用
姜桐桐,李秀琼,赵婷婷,李宏玉,唐强..孤独症谱系障碍中性别差异的研究进展[J].中国当代儿科杂志,2025,27(4):480-486,7.基金项目
黑龙江省自然科学基金重点项目(LH2020H079). （LH2020H079）
