同济大学学报（自然科学版）2025，Vol.53Issue(4)：644-651,8.DOI:10.11908/j.issn.0253-374x.24171
抑菌型除虫菊酯微胶囊的制备及性能
Preparation and Characterization of Antibacterial Natural Pyrethrin Microcapsules
摘要
Abstract
In order to enhance the antibacterial properties of natural pyrethrins,a type of natural pyrethrin microcapsules was prepared using soy protein isolate(SPI)and salicylic acid(SA)as wall materials by complex coagulation method.Single-factor and orthogonal experiments were employed to optimize preparation conditions of pyrethrin microcapsules based on embedding rate and drug loading.The morphology,structure,thermal stability,slow-release capability,storage stability and antibacterial activity were characterized.The results indicate that the optimal conditions are pH 4.25,wall material concentration 2.0％,core-wall ratio 0.5,and SPI/SA mass ratio 2:1.Under these conditions,the microcapsule exhibits an encapsulation efficiency of approximately 30.6％,a maximum drug loading capacity of 3.51％,and an average particle size of 38.3 μm.The microcapsule is spherical and complete,with a crack-free surface.FT-IR analysis confirms the successful embedding of pyrethroid components.Furthermore,the microcapsule demonstrates good thermal stability and sustained release performance at temperatures below 200 ℃.The effective antibacterial properties of salicylic acid against Escherichia coli and Staphylococcus aureus are retained but no antibacterial activity against Candida albicans.The storage stability of microcapsules under low-temperature and dark conditions is moderate,and a recommended shelf life of 3 months is suggested.关键词
天然农药/除虫菊酯/微胶囊/抑菌性/大豆分离蛋白Key words
natural pesticide/pyrethrin/microcapsules/antibacterial activity/soy protein isolate分类
化学化工引用本文复制引用
徐冉,张保晴,刘海容..抑菌型除虫菊酯微胶囊的制备及性能[J].同济大学学报（自然科学版）,2025,53(4):644-651,8.基金项目
中央高校基本科研业务费专项资金(22-4-ZD-09) （22-4-ZD-09）
