中国医疗设备2025，Vol.40Issue(4)：8-12,5.DOI:10.3969/j.issn.1674-1633.20241187
纳秒脉冲电场介导肿瘤电消融的分子生物信号通路
Molecular Biological Signaling Pathways of Tumor Electroablation Mediated by Nanosecond Pulsed Electric Field
摘要
Abstract
Nanosecond pulsed electric field(nsPEF)is an emerging electroablation technology that induces tumor cell electroporation,calcium influx,and reactive oxygen species accumulation by applying a high-intensity electric field in an extremely short duration.This paper summarized the mechanisms of nsPEF in tumor ablation,particularly its specific effects at the cellular and molecular levels.Research indicated that nsPEF induced tumor cell death through various pathways,including intrinsic and extrinsic apoptosis,necrosis,autophagy,and immune response pathways,thereby enhancing anti-tumor immune reactions.Despite the potential of nsPEF in tumor treatment,its application faces challenges such as the need for further elucidation of its mechanisms,optimization of parameters,and improvement of treatment strategies.Future research should continue to explore the application of nsPEF in different types of tumors and integrate it with other treatment modalities to develop more comprehensive and personalized therapeutic approaches,thereby enhancing its clinical efficacy and safety.关键词
纳秒脉冲电场/恶性肿瘤/电消融/信号通路Key words
nanosecond pulsed electric field(nsPEF)/malignant tumor/electroablation/signaling pathways分类
医药卫生引用本文复制引用
董延钊,邹晓迪,周伟杰,刘振锋,陈永刚,吴斌,卢荟..纳秒脉冲电场介导肿瘤电消融的分子生物信号通路[J].中国医疗设备,2025,40(4):8-12,5.基金项目
国家自然科学基金重大仪器项目(82027803). （82027803）
