中国医疗设备2025，Vol.40Issue(4)：13-18,6.DOI:10.3969/j.issn.1674-1633.20241209
纳秒脉冲电场乳腺肿瘤组织消融安全性的临床前动物实验研究
Pre-Clinical Animal Study on the Safety of Breast Tumor Ablation with Nanosecond Pulsed Electric Field
摘要
Abstract
Objective To use nanosecond pulsed electric nield(nsPEF)for minimally invasive ablation of goat breast tissue,to explore the safety of pulsed electric field ablation for breast tissue.Methods Three adult normal female goats were selected.After local anesthesia,the ultrasound-guided transcutaneous ablation of breast tissue was performed with the electrode needle connected with the nanosecond pulsed tumor ablation system.Changes in vital signs of experimental goat during ablation were observed,blood biochemistry were detected before,after and during follow-up,ultrasound images of mammary ablation sites were collected,and pathological samples were taken to compare the pathological changes of mammary tissue before and after ablation.Results The nsPEF technique was successful in the ablation of breast tissue in goats.No adverse reaction occurred during the operation and no muscle tremors or contractions were observed around the breast during ablation.Ultrasound examination found that the ablation effect was significant during the regular follow-up after the operation.There was no significant difference in blood examination before and after operation.The histopathology showed apoptosis and necrosis in the ablated region,and normal tissue morphology in the non-ablated region.Conclusion nsPEF technique is effective and safe for breast ablation in goats,and the minimally invasive ablation operation on large preclinical animals is feasible.关键词
纳秒脉冲电场/乳腺/消融/乳腺肿瘤/微创介入Key words
nanosecond pulsed electric field(nsPEF)/breast/ablation/breast tumor/minimally invasive intervention分类
医药卫生引用本文复制引用
陈璐艳,洪良杰,王宝华,孔海莹,陈永刚,吴斌,陈新华,傅佩芬..纳秒脉冲电场乳腺肿瘤组织消融安全性的临床前动物实验研究[J].中国医疗设备,2025,40(4):13-18,6.基金项目
国家自然科学基金重大仪器项目(82027803). （82027803）
