中国医疗设备2025，Vol.40Issue(4)：19-23,5.DOI:10.3969/j.issn.1674-1633.20241332
纳秒脉冲电场促进伤口愈合的研究进展
Research Progress of Nanosecond Pulsed Electric Field in Promoting Wound Healing
摘要
Abstract
Wound healing is a complex and dynamic physiological process involving multiple stages of biological responses,including hemostasis,inflammation,proliferation,and remodeling.In recent years,nanosecond pulsed electric field(nsPEF)has garnered significant attention for their potential in cellular and tissue repair,demonstrating promising applications in promoting wound healing.This review systematically summarized the fundamental principles of nsPEF and its mechanisms of influence during the wound healing process,exploring its effects on cell proliferation,migration,angiogenesis,and anti-inflammatory and antibacterial actions,as well as its ability to enhance the uptake of drugs and nutrients through electroporation.Although nsPEF is still in the exploratory stage of clinical application,preliminary results from animal models and clinical trials have shown that it can significantly accelerate the healing of acute and chronic wounds while reducing infection rates.However,further research is needed to address questions regarding the effects of different intensities,frequencies,and durations of electric field exposure on treatment outcomes,as well as the applicability to various wound types and long-term safety.Future studies should focus on optimizing the parameters of nsPEF use and combining it with other treatment methods to achieve personalized treatment plans,thereby improving overall efficacy and safety.关键词
纳秒脉冲电场/伤口愈合/信号通路/细胞增殖/电刺激Key words
nanosecond pulsed electric field(nsPEF)/wound healing/signaling pathway/cell proliferation/electrical stimulation分类
医药卫生引用本文复制引用
周伟杰,董延钊,邹晓迪,伊方昱,陈永刚,吴斌,Ahmad Alhaskawi,卢荟..纳秒脉冲电场促进伤口愈合的研究进展[J].中国医疗设备,2025,40(4):19-23,5.基金项目
浙江省卫生健康委医药卫生科技计划项目(2022KY1455). （2022KY1455）
