中国医疗设备2025，Vol.40Issue(4)：24-31,37,9.DOI:10.3969/j.issn.1674-1633.20241460
纳秒脉冲电场在病理性瘢痕治疗中的作用机制及应用前景
Mechanism and Prospective Applications of Nanosecond Pulsed Electric Field in the Treatment of Pathological Scars
摘要
Abstract
Cutaneous scar is an outcome of the physiological wound healing process.Pathological scar,including hypertrophic scars and keloids,arises from the abnormal activity of fibroblasts and excessive accumulation of extracellular matrix.The formation of pathological scars involves a multitude of cell types and intricate molecular signaling pathways.Current therapeutic approaches encompass local steroid injections,radiotherapy,external treatments,laser therapy,cryotherapy,and surgery,yet they exhibit limited efficacy.Nanosecond pulsed electric field(nsPEF)technology,an emerging non-thermal bioelectric treatment modality,activates programmed cell death through ultra-short pulsed electrical energy,exhibiting selectivity for the treatment area with minimal damage to surrounding tissues.nsPEF has demonstrated safety and efficacy in the treatment of cutaneous malignancies and benign lesions.In the context of scar treatment,nsPEF theoretically could induce programmed cell death in fibroblasts,softening the extracellular matrix,thereby providing a novel perspective for improving tissue healing and reducing scarring.Additionally,nsPEF may mitigate scar formation through anti-angiogenic,immunomodulatory effects,and modulation of relevant signaling pathways.However,the specific effects and mechanisms warrant further investigation.Future research will focus on the therapeutic efficacy,protocol optimization,and determination of treatment parameters of nsPEF technology to validate its clinical application value in the treatment of pathological scar.关键词
瘢痕/纳秒脉冲电场/细胞程序性死亡/瘢痕疙瘩/细胞凋亡Key words
scar/nanosecond pulsed electric field/programmed cell death/keloid/apoptosis分类
医药卫生引用本文复制引用
董萱,赵寅,陈新华,包祺..纳秒脉冲电场在病理性瘢痕治疗中的作用机制及应用前景[J].中国医疗设备,2025,40(4):24-31,37,9.基金项目
国家自然科学基金重大仪器项目(82027803) （82027803）
国家自然科学基金(81971864). （81971864）
