中国医疗设备2025，Vol.40Issue(4)：44-49,6.DOI:10.3969/j.issn.1674-1633.20240984
漫射相关光谱在脑血流自动调节中的研究
Study of Diffuse Correlation Spectroscopy in Automatic Regulation of Cerebral Blood Flow
摘要
Abstract
Objective To explore the interaction between cerebral blood flow microcirculation,blood pressure and cerebral autoregulation.Methods Twenty healthy adult subjects were recruited to complete four experimental tasks:upright tilt task,thigh cuff compression task,active standing task and squatting task to induce simultaneous changes of capillary blood flow and blood pressure in the brain.Cerebral blood flow was measured by diffuse correlation spectroscopy,blood pressure was recorded in real time by fingertip blood pressure recording technology,and the data frequency was matched by integer algorithm to ensure the consistency of data processing.In addition,the dynamic changes of blood flow and blood pressure were evaluated quantitatively by setting reaction time,response change rate,integral.Results In the active standing task,blood pressure and blood flow showed significant positive correlation(r=0.65,P=0.036),but no significant correlation was found in other tasks.The speed of blood pressure adjustment in all tasks was faster than that of blood flow,the difference was statistically significant(P<0.05),and the difference of thigh cuff compression task was the most significant(t=8.926,P<0.001).Integral analysis showed a significant positive correlation between thigh cuff compression(r=0.55,P=0.016)and active standing task(r=0.45,P=0.022).These findings suggested that the blood pressure regulation system had a faster response characteristic.Conclusion This study analyzes the relationship between blood pressure and cerebral blood flow through the multi-task paradigm,which can provide experimental basis for quantifying cerebral blood flow autoregulation and provide a priori reference for future quantitative research on cerebral blood flow autoregulation mechanism.关键词
脑部微血流/血压/脑血流自动调节/漫射相关光谱/N阶线性算法/深层组织Key words
cerebral microblood flow/blood pressure/automatic regulation of cerebral blood flow/diffuse correlation spectroscopy(DCS)/N-order linear(NL)algorithm/deep tissue分类
预防医学引用本文复制引用
徐舒宁,桂志国,尚禹..漫射相关光谱在脑血流自动调节中的研究[J].中国医疗设备,2025,40(4):44-49,6.基金项目
国家重点研发计划(2023YFE0202800) （2023YFE0202800）
山西省基础研究计划项目(202203021221097 （）
202203021211100) （）
中北大学研究生科技立项(20231932) （20231932）
山西省研究生教育创新项目(2022Y621). （2022Y621）
