中国医疗设备2025，Vol.40Issue(4)：132-137,157,7.DOI:10.3969/j.issn.1674-1633.20241041
小脑梗死患者脑功能网络的变化及与认知功能的关系研究
Study on the Changes of Brain Functional Network and Its Relationship with Cognitive Function in Patients with Cerebellar Infarction
摘要
Abstract
Objective To investigate the changes in functional connectivity of EEG signals in patients with cerebellar infarction and their relationship with cognitive function.Methods EEG data from 37 cerebellar infarction patients(cerebellar infarction group)and 40 healthy controls(control group)were preprocessed and decomposed into five frequency bands:delta(1-4 Hz),theta(4-8 Hz),alpha(8-13 Hz),beta(13-30 Hz),and gamma(30-45 Hz).Through phase synchronization analysis,the phase locking value was calculated to construct the electrode lead connectivity matrices and compute network attribute parameters,including small-world index,clustering coefficient,local efficiency,global efficiency,shortest path length,and to evaluate the relationships between these network attribute parameters and cognitive function scores.Results The cerebellar infarction group showed significantly increased functional connectivity in the delta and gamma bands(P<0.05)and significantly decreased connectivity in the alpha and beta bands(P<0.05).In the delta band,cerebellar infarction group exhibited significantly increased global efficiency,local efficiency,and clustering coefficient(P<0.05),with considerably decreased small-world index and shortest path length(P<0.05).In the alpha and beta bands,cerebellar infarction group showed significantly reduced global efficiency,local efficiency,and clustering coefficient(P<0.05),with a significantly increased shortest path length(P<0.05).In the gamma band,the local efficiency and clustering coefficient in cerebellar infarction group were significantly higher than those in the control group(P<0.05).Global efficiency,local efficiency,and clustering coefficient were positively correlated with cognitive function scores(P<0.01),while the shortest path length was negatively correlated with cognitive function scores in the cerebellar infarction group(P<0.01).Conclusion Abnormal resting-state brain network connectivity and network attributes in patients with cerebellar infarction are closely related to cognitive dysfunction,providing a basis for exploring more effective diagnostic and therapeutic strategies.关键词
小脑梗死/静息态脑网络/脑电图/相位锁定值/图论分析/认知量表评分Key words
cerebellar infarction/resting-state brain network/electroencephalogram/phase-locked values/cognitive scale score分类
医药卫生引用本文复制引用
蒋明清,吴语丝,阮江海,罗华..小脑梗死患者脑功能网络的变化及与认知功能的关系研究[J].中国医疗设备,2025,40(4):132-137,157,7.基金项目
国家自然科学基金青年科学基金(81804198) （81804198）
四川省科技厅重点研发项目(2024YFFK0142). （2024YFFK0142）
