摘要
Abstract
Objective To explore the differences in the efficacy,satisfaction,adherence,incidence of adverse reactions,and recurrence rates of isotretinoin and oral antibiotics in patients with moderate to severe acne of different skin types.Methods This cohort study selected 200 patients who were treated in the Xuzhou Municipal Hospital from September 2021 to August 2023.20 patients were divided into the oral isotretinoin group and oral antibiotic group respectively,with 40 patients of different skin types.After 4 weeks of treatment,the differences in efficacy,satisfaction,adherence,and incidence of adverse reactions between two groups with moderate to severe acne with different skin types were compared.Recurrence rate of acne during 3 months follow-up were compared between two groups with moderate to severe acne with different skin types.Results In the dry skin group,the effective rate,satisfaction,and adherence of oral isotretinoin were lower than oral antibiotic,while the incidence of adverse reactions and recurrence rate were higher than oral antibiotic,and the differences were statistically significant(all P＜0.05).In the neutral skin group,there was no significant statistical difference in effective rate,satisfaction,adherence,the incidence of adverse reactions,and recurrence rate between the oral isotretinoin group and the oral antibiotic group(P＞0.05).In the sensitive skin group,the effective rate,satisfaction,and adherence of the oral isotretinoin group were lower than the oral antibiotic group,while the recurrence rate was higher than the oral antibiotic group,and the differences were statistically significant(all P＜0.05).In the oily skin group,the satisfaction and adherence of the oral isotretinoin were higher than the oral antibiotic group.The incidence of adverse reactions and recurrence rate were lower than the oral antibiotic group,and the differences were statistically significant(all P＜0.05).In the mixed skin group,there was no statistically significant difference in efficacy,satisfaction,adherence,incidence of adverse reactions,and recurrence rate between the oral isotretinoin group and the oral antibiotic group(P＞0.05).Conclusion The response of patients with moderate to severe acne vulgaris to oral isotretinoin and oral antibiotics varies significantly with different skin types.Patients with dry and sensitive skin may be more suitable for oral antibiotics,while those with oily skin may benefit more from oral isotretinoin.For patients with neutral or mixed skin,the response to both treatment options is similar,and the choice can be made based on the patient's specific circumstances and preferences.关键词
皮肤类型/寻常痤疮/依从性/异维A酸/抗生素Key words
skin type/acne vulgaris/adherence/isotretinoin/antibiotic分类
临床医学
