摘要
Abstract
Narcolepsy(NP)is a rare central sleep disorder,and it is categorized into narcolepsy type1(NT1)and narcolepsy type2(NT2).The main clinical symptoms of NP include daytime lethargy,cataplexy induced by emotions,and sleep paralysis,with a peak onset during adolescence(with an age of 8‒12 years).At present,the pathogenesis of NP re-mains unclear and is associated with various factors such as human leucocyte antigen(HLA),infection,and epigenetic si-lencing,and the selective loss of hypocretin neurons in the hypothalamus is the key pathophysiological mechanism of NP.Pharmacological intervention is currently the main treatment method,and diagnostic delay can be as long as more than 10 years,which not only affects the social activities,academic performance,and work of patients,but also leads to mental health issues such as anxiety and depression.This article reviews the latest research findings in the epidemiology,patho-genesis,and treatment of NT1 and clarifies the deficiencies and controversies in current research,so as to provide new ideas and directions for subsequent studies.关键词
发作性睡病/1型发作性睡病/下丘脑食欲素/人类白细胞抗原免疫基因/猝倒Key words
Narcolepsy/Narcolepsy type1/Hypocretin/Human leucocyte antigen gene/Cataplexy分类
医药卫生
