中风与神经疾病杂志2025，Vol.42Issue(3)：233-238,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0047
抗髓鞘少突胶质细胞糖蛋白IgG抗体相关疾病的临床特征分析
Clinical features of myelin oligodendrocyte glycoprotein-IgG-associated disorders
摘要
Abstract
Objective To investigate the clinical features of myelin oligodendrocyte glycoprotein-IgG-associated disor-ders(MOGAD).Methods A retrospective analysis was performed for the clinical data of nine patients with MOGAD who were admitted to our department.Results Among the nine patients with MOGAD,there were five male patients and four female patients,with a median age of onset of 29.0 years.The main clinical symptoms included optic neuritis in five patients,cerebral symptoms(including mental symptoms)in five patients,seizures in four patients,brainstem symptoms in three patients,pyramidal signs in three patients,cerebellar symptoms in three patients,rectal and bladder dysfunction in three patients,myelitis in two patients,paresthesia in two patients,and comorbidity with autoimmune encephalitis in one patient.All patients tested positive for serum MOG-IgG,and two patients tested positive for MOG-IgG in cerebrospinal fluid.MRI showed that cerebral lesions mainly involved the midline structure and deep gray matter,and there were four patients(44.4%)with lesions in the midbrain,the pons,and the medulla oblongata and four patients(44.4%)with lesions in the fourth ventricle;spi-nal lesions often involved long segments(≥3 segments),and there were two patients with lesions in cervical spinal cord and one patient with lesions in the thoracic spinal cord.All nine patients received immunotherapy in the acute stage,with a mean Ex-panded Disability Status Scale score of(3.94±2.28)for neurological function assessment.Three patients experienced recur-rence during the median follow-up time of 36.0 months,among whom two patients had myelitis.Conclusion There was no sig-nificant sex difference in the prevalence rate of MOGAD,and the age of onset of MOGAD is earlier than that of multiple sclerosis and neuromyelitis optica spectrum disorder.Optic neuritis is the most important clinical phenotype of MOGAD,and MOGAD patients with myelitis phenotype all have longitudinal long-segment lesions of the spinal cord.The different clinical phenotypes of MOGAD may be associated with recurrence rate.关键词
MOG抗体相关疾病/中枢神经系统脱髓鞘/临床表型/预后Key words
Myelin oligodendrocyte glycoprotein-IgG-associated disorders/Central nervous system demyelin-ation/Clinical phenotype/Prognosis分类
临床医学引用本文复制引用
刘曌,王丽君,万东君..抗髓鞘少突胶质细胞糖蛋白IgG抗体相关疾病的临床特征分析[J].中风与神经疾病杂志,2025,42(3):233-238,6.基金项目
甘肃省卫生行业科研计划项目(GSWSKY-2019-64) （GSWSKY-2019-64）
甘肃省青年科技基金计划项目(20JR5RA590) （20JR5RA590）
联勤保障部队第九四〇医院专项培育项目(2021yxky018) （2021yxky018）
