彭翠林 1胡苑铃 1刘爱群 2彭忠兴 2洪铭范 2周志华2
作者信息
- 1. 广东药科大学附属第一医院神经内科,广东 广州 510080
- 2. 广东药科大学附属第一医院神经内科,广东 广州 510080||广东药科大学附属第一医院中西医结合神经病学研究所,广东 广州 510080
- 折叠
摘要
Abstract
Objective Wernekinck commissure syndrome(WCS)is a rare syndrome in clinical practice caused by Wernekinck commissure lesions,with the clinical manifestations of bilateral limb ataxia and dysarthria.This article ana-lyzes the clinical features and other characteristics of WCS caused by ischemic stroke through a literature review,in order to improve the understanding of this syndrome among clinicians.Methods CNKI,Wanfang Data,and PubMed data-bases were searched for articles on WCS caused by ischemic stroke,and the clinical manifestations of reported WCS cases were analyzed and summarized.Results Among the 57 patients with WCS caused by ischemic stroke,48(84.2%)had bilateral cerebellar ataxia,48(84.2%)had dysarthria,36(63.2%)had varying degrees of limitation of eye movement,36(63.2%)had dizziness,30(52.6%)had nystagmus,12(21.1%)had disturbance of consciousness,9(15.8%)had Holmes tremor,and 7(12.3%)had palatal myoclonus.When lesions involved Wernekinck commissure and the adjacent struc-tures,patients might have the manifestations such as bilateral ataxia,dysarthria,limitation of eye movement,nystagmus,Holmes tremor,and disturbance of consciousness.Conclusion WCS caused by ischemic stroke has the main manifesta-tions of bilateral limb ataxia,dysarthria,and eye movement disorder,and palatal myoclonus is relatively rare in the early stage and usually occurs along with hypertrophy of the inferior olivary nucleus in the late stage.关键词
Wernekinck连合综合征/Wernekinck连合/小脑上脚交叉/软腭肌阵挛/肥厚性下橄榄核变性Key words
Wernekinck commissure syndrome/Wernekinck commissure/Decussation of superior cerebellar peduncle/Palatal myoclonus/Hypertrophy of the inferior olivary nucleus分类
临床医学
