中风与神经疾病杂志2025，Vol.42Issue(3)：262-266,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0053
O-GlcNAc糖基化修饰在缺血性脑卒中作用的研究进展
Research advances in the role of O-GlcNAc glycosylation in ischemic stroke
摘要
Abstract
O-GlcNAc glycosylation,as the most extensive type of glycosylation modification,is involved in the development and prognosis of ischemic stroke by regulating excitatory toxicity,mitochondrial function,synaptic plasticity,and immune metabolism and inhibiting endoplasmic reticulum stress and inflammatory response,and regulation of O-GlcNAc glycosylation is considered a promising therapeutic target for ischemic stroke.This article reviews the characteristics and specific mechanisms of O-GlcNAc glycosylation in ischemic stroke,in order to provide new ideas for the prevention and treatment of ischemic stroke.关键词
翻译后修饰/糖基化/缺血性脑卒中Key words
Post-translational modification/Glycosylation/Ischemic stroke分类
医药卫生引用本文复制引用
宁文华,刘伊滢,李思颖,王海明..O-GlcNAc糖基化修饰在缺血性脑卒中作用的研究进展[J].中风与神经疾病杂志,2025,42(3):262-266,5.基金项目
国家自然科学基金(82305400) （82305400）
河南省医学科技攻关计划联合共建项目(LHGJ20220352) （LHGJ20220352）
