中风与神经疾病杂志2025，Vol.42Issue(3)：267-272,6.DOI:10.19845/j.cnki.zfysjjbzz.2025.0054
认知障碍的蛋白组学研究进展
Advances in proteomic research on cognitive disorder
摘要
Abstract
Cognition is the intelligent processing of the brain,which affects the acquisition and realization of knowledge in the body,including learning,memory,thinking,language,emotion,spirit,and other psychological and social activities.Cognitive impairment refers to abnormalities in the processing of higher-order intellectual activities in the brain,such as learning,memory,thinking,and judgment,which leads to severe learning and memory difficulties,and it is often accompanied by pathological developments including aphasia and apraxia,which is mainly caused by Alzheimer disease,cerebrovascular diseases,and traumatic brain injury.At present,the etiology of cognitive impairment remains unclear.Nowadays,with the continuous development of modern science and technology,proteomics technology has been widely used in the field of clinical medical research and can provide a scientific basis for the diagnosis and treatment of diseases and the development of new drugs.This article reviews the research advances in proteomics technologies,humoral proteomics of cognitive disorders,brain tissue proteomics,and proteomics research in cognitive disorders at high altitude,in order to further reveal the application and development of proteomics in cognitive disorders.关键词
认知障碍/蛋白组学技术/生物学标志物Key words
Cognitive disorder/Proteomics technology/Biomarkers分类
医药卫生引用本文复制引用
裴江燕,吉维忠..认知障碍的蛋白组学研究进展[J].中风与神经疾病杂志,2025,42(3):267-272,6.基金项目
科技成果转化专项项目(2023-SF-107) （2023-SF-107）
2022年青海省昆仑英才·高端创新创业人才项目(QHKLYC-GDCXCY-2022-193) （QHKLYC-GDCXCY-2022-193）
