中风与神经疾病杂志2025，Vol.42Issue(3)：284-288,5.DOI:10.19845/j.cnki.zfysjjbzz.2025.0057
锌稳态在脑小血管病发生发展中病理生理的作用
The pathophysiological role of zinc homeostasis in the development and progression of cerebral small vessel disease
摘要
Abstract
Cerebral small vessel disease(CSVD)refers to a series of clinical,imaging,and pathological syndromes caused by various etiologies affecting arterioles,capillaries,and venules in the brain,and the main clinical manifestations of CSVD include cognitive impairment,gait and balance disorders,urinary incontinence,and mental and behavioral disorders such as depression,anxiety,apathy,and personality changes.At present,the pathophysiological mechanism of CSVD remains unclear.As one of the most important trace elements in the human body,zinc ions play an important role in the development of the nervous system,and the change in zinc ion concentration will affect a variety of nervous system diseases;therefore,the research on the association between zinc ion homeostasis and the development and progression of cSVD has gradually become a hot topic.This article reviews the mechanism of the development and progression of CSVD,the role of zinc ions in the nervous system,the association between zinc ions and the development and progression of CSVD,and the latest research advances.关键词
锌稳态/脑小血管病/发病机制/神经系统疾病/神经毒性Key words
Zinc homeostasis/Cerebral small vessel disease/Pathogenesis/Nervous system disease/Neurotoxicity分类
医药卫生引用本文复制引用
曹乐,张凯,黄文帅,梁文昭..锌稳态在脑小血管病发生发展中病理生理的作用[J].中风与神经疾病杂志,2025,42(3):284-288,5.基金项目
吉林省省直厅局项目(SY2021SCZ16) （SY2021SCZ16）
