中国美容医学2025，Vol.34Issue(4)：6-9,4.
强脉冲光联合重组牛碱性成纤维细胞生长因子对兔激素依赖性皮炎动物模型的作用机制研究
Mechanism Study on Intense Pulsed Light Combined with Recombinant Bovine Basic Fibroblast Growth Factor on Rabbit Model of Hormone-dependent Dermatitis
摘要
Abstract
Objective To observe the changes of collagen fiber and MMP1 in rabbit model of corticosteroid-dependence dermatitis before and after treatment with IPL and rb-bFGF gel.Methods The rabbit model of glucocorticoid-dependent dermatitis was established by clobetasol propionate.The back of each rabbit was randomly divided into four groups(four quadrants):Group A was the control group(no treatment),Group B was treated with rb-bFGF gel.Group C was irradiated with IPL once,Group D combined application of both.The changes of collagen fiber and MMP1 expression in skin tissues of each group were observed at different periods after IPL irradiation.Results There were differences between the model rabbits and the normal rabbits in the decrease of collagen fiber and the increase of MMP1 expression.After treatment,in contrast with the control group,the expression of collagen fibers and MMP1 in the rb-bFGF gel group showed no significant difference,the content of collagen fiber increased and the expression of MMP1 decreased significantly between the IPL irradiation group and the combined treatment group.Conclusion These results indicate that both IPL and IPL combined with rb-bFGF can be regulated the secretion of MMP1 and promote the regeneration of collagen fiber,and rb-bFGF combined with IPL is the most efffective treatment,which can promote the repair of skin barrier more efficiently.关键词
激素依赖性皮炎/强脉冲光/重组牛碱性成纤维细胞生长因子凝胶/胶原纤维/基质金属蛋白酶Key words
corticosteroid-dependence dermatitis/intense pulsed light/recombinant bovine basic fibroblast growth factor gel/collagenous fiber/matrix metalloproteinase分类
医药卫生引用本文复制引用
陈茜,朱睿,杨文佳,陈洪铎,徐天华..强脉冲光联合重组牛碱性成纤维细胞生长因子对兔激素依赖性皮炎动物模型的作用机制研究[J].中国美容医学,2025,34(4):6-9,4.基金项目
深圳市南山区教育(卫生)科技项目[编号:2020004(重点)] （卫生）
