摘要
Abstract
Objective Exploring the correlation between changes in serum SIRT1 levels in burn patients and their inflammatory factors and degree of wound healing.Methods Eighty patients with deep second-degree burn wounds admitted to the author's hospital from August 2019 to August 2022 were selected as the observation group,and 80 healthy physical examination subjects were selected as the control group during the same period.Serum SIRT1 levels of the control group and the observation group were detected and compared.According to the median of serum SIRT1 level in the observation group,the group was divided into high SIRT1 expression group and low SIRT1 expression group.Treated the observation group and evaluated the degree of wound healing after 14 days of treatment.Compared the levels of inflammatory factors and wound healing degree between patients with high serum SIRT1 expression and those with low serum SIRT1 expression.Pearson analyzed the correlation between serum SIRT1 expression levels and the level of inflammatory factors in burn patients with wound healing degree.Results The serum SIRT1 level in observation group was(2.44±1.24)ng/ml,which was higher than that in control group(1.65±0.72)ng/ml(P＜0.05).The median serum SIRT1 level of 80 burn patients in the observation group was 2.493 ng/ml.According to this group,46 cases were in the high expression group of SIRT1 and 34 cases were in the low expression group,and there was no statistical significance in the general data between the two groups(P＞0.05).Before treatment,the levels of CRP and IL-6 in SIRT1 high expression group were lower than those in SIRT1 low expression group(P＜0.05).After the same treatment,the wound healing degree of SIRT1 high expression group was higher than that of SIRT1 low expression group(P＜0.05).Pearson correlation analysis showed that serum SIRT1 level in patients with deep second-degree burn was positively correlated with the degree of wound healing(r=0.365 9,P=0.000 8),and negatively correlated with the levels of inflammatory factors CRP and IL-6(rCRP=-0.5757,rIL-6=-0.5233,All P＜0.001).Conclusion Serum SIRT1 level increased in patients with deep second-degree burn wounds,and was positively correlated with the degree of wound healing,and negatively correlated with the levels of inflammatory factors CRP and IL-6.关键词
烧伤/创面愈合/愈合程度/SIRT1/炎症因子/相关性Key words
burns/wound healing/SIRT1/inflammatory factor/relevance分类
医药卫生
