中国美容医学2025，Vol.34Issue(4)：59-64,6.
序贯激光结合32P同位素敷贴协同治疗烧伤后增生性瘢痕的疗效及对瘢痕组织TGF-β1、BMP-7的影响
Synergistic Therapeutic Efficacy of Sequential Laser Treatment Combined with 32P Isotope Patch in Treating Hypertrophic Scars after Burn and its Impact on TGF-β1 and BMP-7 in Scar Tissue
彭梦龙 1桂艳鸾 2王荣1
作者信息
- 1. 黄冈市中心医院 整形美容科 湖北 黄冈 438000
- 2. 黄冈市中心医院 皮肤科 湖北 黄冈 438000
- 折叠
摘要
Abstract
Objective To investigate the synergistic therapeutic efficacy of sequential laser treatment combined with 32P isotope patch in treating hyperplastic scar after burn and its impact on TGF-β1 and BMP-7 in scar tissue.Methods A total of 124 patients with hypertrophic burn scars admitted to the author's hospital from March 2022 to March 2023 were randomly divided into a control group and an observation group,with 62 patients in each group.Patients in the control group received sequential laser treatment,while patients in the observation group were treated with 32P isotope patch after laser treatment.The total effective rate,visual analog scale(VAS)for itching,Vancouver scar scale(VSS)score,short form 36 health survey(SF-36)score,levels of TGF-β1 and BMP-7 in scar tissue,and incidence of adverse reactions were compared between the two groups.A 6-month follow-up was conducted to observe the recurrence rate in both groups.Results After the last treatment,the total effective rate and SF-36 score in the observation group were higher than those in the control group(P＜0.05).The VAS score and VSS score in the observation group were lower than those in the control group(P＜0.05).The level of TGF-β1 was lower and BMP-7 level was higher in the observation group compared to the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).After a 6-month follow-up,the recurrence rate in the observation group was lower than that in the control group(P＜0.05).Conclusion Sequential laser treatment combined with 32P isotope patch synergistically improves clinical symptoms and quality of life in patients with hyperplastic scar after burn,reduces the risk of recurrence,and simultaneously regulates the balance of TGF-β1 and BMP-7 in the process of scar formation,inhibiting fibroblast proliferation and collagen deposition.关键词
烧伤/序贯激光/32P同位素敷贴/增生性瘢痕/转化生长因子β1/骨形态发生蛋白7Key words
burn/sequential laser/32P isotope patch/hypertrophic scars/TGF-β1/BMP-7分类
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彭梦龙,桂艳鸾,王荣..序贯激光结合32P同位素敷贴协同治疗烧伤后增生性瘢痕的疗效及对瘢痕组织TGF-β1、BMP-7的影响[J].中国美容医学,2025,34(4):59-64,6.
