中国真菌学杂志2025，Vol.20Issue(1)：34-38,5.
儿童念珠菌血症的菌株分布及耐药性分析
Species distribution and drug resistance analysis of candidemia in children
摘要
Abstract
Objective To investigate the species distribution and resistance profile of children's candidemia,and to provide evidence for prevention and reasonable diagnosis and treatment of candidiemia.Methods A retrospective analysis was carried out to analysis the clinical data of children with candidiemia hospitalized in Hebei Children's Hospital from January 2013 to December 2022.The demographic characteristics,species distribution,department source and antifungal drug sensitivity were analyzed.Results A total of 103 children with non-repetitive candidiemia were enrolled,including 70 males(67.96%)and 55 infants aged 29 days to 3 years(53.40%).Candida albicans(67 cases,65.05%)had the highest detection rate,followed by C.parapsilosis(16 cases,15.53%)and C.tropicalis(11 cases,10.68%).Over the last 10 years,the proportion of non-albicans Candida isolated in children with candidiemia showed an increasing trend,while the proportion of C.albicans showed a decreasing trend.The patients with candidemia were mainly from the surgery departmentsurgery department(47/103,45.63%),followed by the neonatology department(23/103,22.33%)and hematology department(13/103,12.62%).The susceptibility(wild type)rates of C.albicans,C.parapsilosis,C.tropicalis and C.glabrata to 5-fluorocytosine and amphotericin B were 100%.The sensitivity rates of C.parapsilosis and C.glabrata to azole antifungal drugs were 100%.The sensitivity of C.albicans to azole was higher than 92%.However,the resistance rates of C.tropicalis to fluconazole,itraconazole and voriconazole were 54.55%,36.36%and 45.45%,respectively.Conclusions Children with candidiemia usually occured in infants under 3 years of age,mainly caused by Candida albicans,and non-albicans Candida showing an increasing trend with time.5-fluorocytosine and amphotericin B could be used in the empirical treatment of candidiemia in our hospital.Azole antifungal drugs should be used with care for bloodstream infections caused by C.tropicalis.关键词
念珠菌血症/儿童/菌株分布/药物敏感性Key words
candidiemia/children/species distribution/drug resistance分类
临床医学引用本文复制引用
赵梦川,李圆龙,郭映辉,张文超,邢建,王会茹,李梅,段素霞,翟宇,徐茜茹,王冬雪..儿童念珠菌血症的菌株分布及耐药性分析[J].中国真菌学杂志,2025,20(1):34-38,5.基金项目
河北省政府资助临床医学优秀人才培养项目(ZF2023207) （ZF2023207）
