中国真菌学杂志2025，Vol.20Issue(1)：39-44,51,7.
ICU患者侵袭性念珠菌病的临床特征、耐药性及预后分析
Clinical characteristics,drug resistance and prognostic analysis of invasive candidiasis in ICU patients
周海春 1邹星宇 1王俊文 1郭云云1
作者信息
- 1. 界首市中医院重症医学科,界首 236500
- 折叠
摘要
Abstract
Objective To investigate the clinical characteristics,drug resistance,and prognostic analysis of invasive candidiasis(IC)in intensive care unit(ICU)patients.Methods A retrospective analysis was conducted on 356 patients with persistent fever admitted to the ICU of our hospital from October 2020 to September 2024.Patients were divided into two groups based on whether they developed IC:the IC group(n=89)and the non-IC group(n=267).The distribution of Candida species and their drug resistance were statistically analyzed,as well as the outcomes and clinical endpoints of the two groups.Results Among the 89 cases in the IC group,97 strains of Candida were identified,with the highest proportion being C.albicans(44 strains,45.36%),and the most common specimen for fungal isolation was urine.Among the 97 strains of Candida underwent susceptibility testing,C.tropicalis showed the most severe drug resistance(46.15%),with the highest overall resistance to itraconazole(18 strains,18.56%),and the lowest resistance to caspofungin(0.00%).The duration of ICU stay and mechanical ventilation use in the IC group were significantly higher than those in the non-IC group(P<0.05),and the difference in the activity of daily living(ADL)scores at admission and discharge from the ICU was significantly higher in the IC group(P<0.05);the survival rate was significantly lower in the IC group(P<0.05).Pearson correlation analysis showed that IC in ICU patients was significantly positively correlated with the duration of ICU stay and mechanical ventilation use(P<0.05),and significantly negatively correlated with the difference in ADL scores(P<0.05).Conclusion In ICU patients who developed secondary IC,C.albicans was the most frequently isolated fungus,and urine was the specimen with the highest detection rate of fungal strains.C.tropicalis showed the highest antifungal resistance,with the highest resistance to itraconazole,and the best sensitivity to caspofungin.The prognosis and clinical outcomes of ICU patients with secondary IC were relatively poorer.关键词
侵袭性念珠菌病/重症监护室/菌种分布/耐药性/预后Key words
invasive candidiasis/intensive care unit/species distribution/drug resistance/prognosis分类
临床医学引用本文复制引用
周海春,邹星宇,王俊文,郭云云..ICU患者侵袭性念珠菌病的临床特征、耐药性及预后分析[J].中国真菌学杂志,2025,20(1):39-44,51,7.
