Abstract
Objective To explore the distribution of fungal species and risk factors for deep fungal infections in critically ill patients.Method From August 2022 to August 2024,1093 patients from the Intensive Care Unit of Chongqing Red Cross Hospital(Jiangbei District People's Hospital)in Chongqing were collected.Retrospective analysis of the occurrence of deep fungal infections,statistical analysis of the fungal infection sites and bacterial species distribution of patients,and classification into uninfected group and fungal infection group based on whether they are infected or not.In this paper,univariate and multivariate logistic regression analysis was carried out on age,sex,obesity,diabetes,hypertension,smoking history,drinking history,hypoproteinemia,neutropenia,chemotherapy history,gastric tube indwelling,hypoproteinemia,immunosuppressants,glucocorticoids,continuous parenteral nutrition,mechanical ventilation,broad-spectrum antibiotics,indwelling urinary catheter,central venous catheterization and other factors.Result Among 1093 patients admitted to the intensive care department of our hospital,82 cases of deep fungal infections occurred,with an incidence rate of 7.50%;The main infection sites are the lower respiratory tract(64.63%),urinary tract(14.63%),and blood(7.32%).A total of 88 strains of fungi were detected in 82 cases of deep infection,mainly including Candida albicans(44.32%),Candida glabrata(21.59%),Candida famata(12.50%),and Candida tropicalis(11.36%).Through univariate analysis,there was a statistically significant difference(P<0.05)between the non infection group and the fungal infection group in terms of age≥60 years,hypoalbuminemia,immunosuppressants,glucocorticoids,continuous parenteral nutrition,mechanical ventilation,broad-spectrum antibiotics,indwelling catheterization,and central venous catheterization.After multiple factor analysis,age≥60 years,hypoalbuminemia,immunosuppressants,glucocorticoids,continuous parenteral nutrition,mechanical ventilation,broad-spectrum antibiotics,indwelling catheterization,and central venous catheterization were identified as risk factors for deep fungal infections in the intensive care unit(P<0.05).Conclusion The sites of deep fungal infections in the intensive care unit of a hospital in Chongqing are mainly in the lower respiratory tract,urinary tract,and blood.The fungal species are mainly Candida albicans,Candida glabrata,Candida famata,and Candida tropicalis.There are multiple risk factors for deep fungal infections in critically ill medical patients.Therefore,we should take it seriously.关键词
重症医学科/深部真菌感染/危险因素Key words
intensive care unit/deep fungal infections/risk factors分类
临床医学
