中国实用外科杂志2025，Vol.45Issue(3)：294-298,5.DOI:10.19538/j.cjps.issn1005-2208.2025.03.11
营养治疗在肠外瘘病人中的应用及临床价值
Application and clinical value of nutritional support therapy in patients with enterocutaneous fistula
摘要
Abstract
Enterocutaneous fistula(ECF)is a critical emergency in gastrointestinal surgery,typically caused by surgical trauma,infection,inflammatory bowel disease,or malignancy.The progression of this condition is often associated with hypermetabolism,negative nitrogen balance,malnutrition,and electrolyte imbalances,severely affecting clinical outcomes and increasing mortality rates.Accurate nutritional support is essential to meet the patient's energy and nutritional needs,regulate the systemic metabolic state,promote tissue repair,and enhance immune function.The staged nutritional support treatment is crucial for patients'recovery and is divided into three major phases:the infection phase,the phase of living with the fistula,and the perioperative phase.Nutritional strategies for each stage focus on infection control,correction of electrolyte imbalances,and the gradual restoration of enteral and parenteral nutrition,respectively,with adequate protein and energy intake promoting fistula healing and disease stabilization.Early,appropriate nutritional support not only enhances the self-healing rate of ECF patients but also significantly reduces mortality.In particular,during the infection phase,a timely combination of enteral and parenteral nutrition effectively maintains the patient's nutritional status and prevents complications.Specific trace elements such as zinc,selenium,and immune-nutrients(e.g.,ω-3 fatty acids and glutamine)play an essential role in the recovery of ECF patients.With advancements in technology,emerging techniques like 3D-printed fistula stents and functionalized biological patches provide innovative solutions for clinical treatment,further optimizing personalized treatment strategies and potentially improving treatment outcomes and patient prognosis.关键词
肠外瘘/营养治疗/阶段性治疗Key words
enterocutaneous fistula/nutritional support thera-py/staged treatment分类
医药卫生引用本文复制引用
杨帆,王新颖..营养治疗在肠外瘘病人中的应用及临床价值[J].中国实用外科杂志,2025,45(3):294-298,5.基金项目
国家自然科学基金面上项目(No.82170575,No.82370900) （No.82170575,No.82370900）
江苏省医学创新中心项目(No.CXZX202217) National Natural Science Foundation of China(General Program,No.82170575,No.82370900) （No.CXZX202217）
Jiangsu Provincial Medical Innovation Center Program(No.CXZX202217) （No.CXZX202217）
