中国当代儿科杂志2025，Vol.27Issue(4)：404-409,6.DOI:10.7499/j.issn.1008-8830.2411003
胰岛素抵抗与子宫体积在特发性中枢性性早熟女童中的关联研究
Association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty
张红如 1肖雅 1姜书琴 1孙俊 1史文慧 1李锦波 1杨莹 1王伟1
作者信息
- 1. 郑州大学第三附属医院/河南省妇幼保健院儿科,河南 郑州 450052
- 折叠
摘要
Abstract
Objective To investigate the association between insulin resistance and uterine volume in girls with idiopathic central precocious puberty(ICPP).Methods A retrospective study was conducted involving 61 girls diagnosed with ICPP who visited the pediatric growth and development clinic of the Third Affiliated Hospital of Zhengzhou University between January 2022 and September 2024,designated as the ICPP group,and 61 normally developing girls as the control group.The differences in insulin resistance index(homeostasis model assessment of insulin resistance,HOMA-IR),uterine volume,and other indicators between the two groups were compared,and the relationship between insulin resistance and uterine volume in these girls was analyzed.Results The uterine volume and HOMA-IR level in the ICPP group were significantly higher than those in the control group(P＜0.05).Correlation analysis revealed that there was a positive correlation between HOMA-IR level and uterine volume in the ICPP group(rs=0.643,P＜0.001).Multiple linear regression analysis indicated that as HOMA-IR increased,uterine volume in the girls tended to increase(P＜0.05).Conclusions There is an association between insulin resistance and uterine volume in girls with ICPP,and as HOMA-IR increases,uterine volume in the girls also increases.关键词
特发性中枢性性早熟/胰岛素抵抗/子宫体积/下丘脑-垂体-性腺轴/儿童Key words
Idiopathic central precocious puberty/Insulin resistance/Uterine volume/Hypothalamic-pituitary-gonadal axis/Child引用本文复制引用
张红如,肖雅,姜书琴,孙俊,史文慧,李锦波,杨莹,王伟..胰岛素抵抗与子宫体积在特发性中枢性性早熟女童中的关联研究[J].中国当代儿科杂志,2025,27(4):404-409,6.
