Abstract
Objective To systematically evaluate the prevalence and risk factors of non-alcoholic fatty liver disease(NAFLD)in overweight and obese children and adolescents in China.Methods Databases including China National Knowledge Infrastructure,Wanfang Data,VIP Database,China Biomedical Literature Database,PubMed,Embase,Web of Science,and Cochrane Library were searched,from database inception to October 2024.Two researchers independently screened the literature,extracted data,and assessed the quality of the studies according to inclusion and exclusion criteria.A Meta analysis was conducted using Stata 16.0 software.Results A total of 42 studies involving 16 481 overweight and obese children and adolescents were included.The Meta analysis results showed that the prevalence of NAFLD among overweight and obese children in China was 43%(95%CI:37%-48%).Factors associated with NAFLD included being male(OR=1.61,95%CI:1.17-2.04),increased weight(MD=10.33,95%CI:9.08-11.57),increased waist circumference(MD=5.49,95%CI:3.36-7.62),longer duration of obesity(MD=0.31,95%CI:0.02-0.61),higher body mass index(MD=3.11,95%CI:2.07-4.16),elevated fasting blood glucose levels(MD=0.17,95%CI:0.06-0.29),higher triglyceride levels(MD=0.32,95%CI:0.17-0.47),elevated total cholesterol levels(MD=0.15,95%CI:0.10-0.21),higher low-density lipoprotein cholesterol levels(MD=0.14,95%CI:0.04-0.23),increased alanine aminotransferase levels(MD=24.39,95%CI:18.57-30.20),increased aspartate aminotransferase levels(MD=12.49,95%CI:9.67-15.32),elevated serum insulin levels(MD=4.47,95%CI:2.57-6.36),higher homeostasis model assessment-insulin resistance(MD=0.45,95%CI:0.30-0.59),and elevated uric acid levels(MD=55.91,95%CI:35.49-76.32)(P＜0.05).Conclusions The prevalence of NAFLD among overweight and obese children and adolescents in China is high.Male gender,increased weight,increased waist circumference,prolonged obesity duration,higher body mass index,dyslipidemia,and elevated levels of fasting blood glucose,liver enzymes,serum insulin,homeostasis model assessment-insulin resistance,and uric acid are potential risk factors for NAFLD in this population.关键词
非酒精性脂肪性肝病/超重/肥胖/患病率/危险因素/Meta分析/儿童/青少年Key words
Non-alcoholic fatty liver disease/Overweight/Obesity/Prevalence/Risk factor/Meta analysis/Child/Adolescent
