中国当代儿科杂志2025，Vol.27Issue(4)：438-443,6.DOI:10.7499/j.issn.1008-8830.2411069
白光胃镜下内镜征象诊断儿童幽门螺杆菌感染的临床研究
Diagnostic value of endoscopic findings under white light gastroscopy for Helicobacter pylori infection in children
摘要
Abstract
Objective To explore the clinical value of endoscopic findings under white light gastroscopy in diagnosing Helicobacter pylori(Hp)infection in children.Methods A retrospective analysis was conducted on the clinical data of 340 children who underwent gastroscopy and gastric mucosa tissue Hp culture from July 2022 to June 2023 in the Department of Gastroenterology at Wuxi Children's Hospital due to upper gastrointestinal symptoms.Based on the results of Hp culture,the children were categorized into an Hp-infected group(146 cases)and a non-infected group(194 cases).The detection rates of various endoscopic findings in the gastric mucosa between the two groups were compared,and the association between each endoscopic finding and different Hp infection statuses was analyzed,as well as the diagnostic value of each endoscopic finding under different Hp infection statuses.Results The proportions of white mucus,diffuse redness,mucosal edema,enlarged folds,chicken skin-like changes,and ulcers in the Hp-infected group were higher than those in the non-infected group(P＜0.05),while the proportions of regular arrangement of collecting venules(RAC)and ridge-like redness were lower in the Hp-infected group compared to the non-infected group(P＜0.05).Multivariate logistic regression analysis showed that diffuse redness,enlarged folds,mucosal edema,and chicken skin-like changes were closely associated with Hp infection(P＜0.05),while RAC and ridge-like redness were closely associated with the absence of Hp infection(P＜0.05).Receiver operating characteristic curve analysis indicated that the area under the curve for diffuse redness,enlarged folds,mucosal edema,and chicken skin-like changes in predicting Hp infection was 0.798,0.731,0.782,and 0.760,respectively(P＜0.05).The area under the curve for RAC and ridge-like redness in predicting the absence of Hp infection was 0.861 and 0.589,respectively(P＜0.05).Conclusions Endoscopic findings under white light gastroscopy are associated with Hp infection in children,with diffuse redness,mucosal edema,chicken skin-like changes,and enlarged folds showing significant diagnostic value for Hp infection.关键词
幽门螺杆菌/白光胃镜/内镜征象/儿童Key words
Helicobacter pylori/White light gastroscopy/Endoscopic finding/Child引用本文复制引用
周仁民,陈颖,林琼..白光胃镜下内镜征象诊断儿童幽门螺杆菌感染的临床研究[J].中国当代儿科杂志,2025,27(4):438-443,6.基金项目
无锡市卫生健康委妇幼健康项目(FYKY202108) （FYKY202108）
无锡市医学创新团队(CXTD2021011). （CXTD2021011）
