中国当代儿科杂志2025，Vol.27Issue(4)：444-450,7.DOI:10.7499/j.issn.1008-8830.2409021
肠道菌群与食物过敏的因果关联:一项孟德尔随机化分析
Causal association between gut microbiota and food allergy:a Mendelian randomization analysis
摘要
Abstract
Objective To analyze the potential causal relationship between gut microbiota and food allergy(FA)using two-sample Mendelian randomization(MR)methods.Methods Data from genome-wide association studies on gut microbiota and FA were utilized.MR analysis was conducted employing inverse variance weighting,MR-Egger regression,and weighted median methods to assess the causal relationship between gut microbiota and FA.Cochrane's Q test was used to evaluate heterogeneity of instrumental variables,MR-PRESSO analysis was conducted to test for outliers and pleiotropy,and MR-Egger regression was employed to assess horizontal pleiotropy.The"leave-one-out"method was used to evaluate the impact of removing individual single nucleotide polymorphisms on the causal relationship.Results Inverse variance weighting analysis revealed that the phylum Verrucomicrobia,family Verrucomicrobiaceae,order Verrucomicrobiales,genus Ruminococcaceae UCG013,and genus Akkermansia were negatively associated with FA(P＜0.05).Sensitivity analyses confirmed the reliability of the findings,indicating no heterogeneity or pleiotropy present.Conclusions There is a causal relationship between gut microbiota and FA,with Verrucomicrobia,Verrucomicrobiaceae,Verrucomicrobiales,Ruminococcaceae UCG013,and Akkermansia potentially reducing the risk of developing FA.These findings provide potential targets for the treatment and prevention of FA;however,further research is needed to explore the specific mechanisms by which the microbiota influence FA.关键词
食物过敏/孟德尔随机化/肠道菌群/疣微菌纲/Ruminococcaceae UCG013属/阿克曼氏菌属Key words
Food allergy/Mendelian randomization/Gut microbiota/Verrucomicrobia/Ruminococcaceae UCG013/Akkermansia引用本文复制引用
胡丽鑫,范国振,马慧,李蕾,王芳,曲政海,管仁政..肠道菌群与食物过敏的因果关联:一项孟德尔随机化分析[J].中国当代儿科杂志,2025,27(4):444-450,7.基金项目
国家自然科学基金项目(82300389) （82300389）
山东省医药卫生科技发展计划项目(202212070731). （202212070731）
