中药材2024，Vol.47Issue(9)：2233-2237,5.DOI:10.13863/j.issn1001-4454.2024.09.016
台东荚蒾化学成分及抗炎活性研究
Study on Chemical Constituents of Viburnum taitoense and Anti-inflammatory Activity
摘要
Abstract
Objective:To study the chemical constituents and anti-inflammatory activity of Viburnum taitoense.Methods:The chemi-cal constituents from the ethyl acetate extract of Viburnum taitoense were isolated and purified by various column chromatography and semi-preparative liquid methods.The stuctures were identified by modern spectral techniques.The anti-inflammatory activities were e-valuated by against NO production form LPS stimulated RAW264.7 cell.Results:Fourteen compounds were isolated from Viburnum tai-toense and identified as 3β-acetoxy-17β-hydroxy-28-norolean-12-ene(1),3-O-acetyl oleanolic aldehyde(2),3β-hydroxy-3-deoxymoronic acid(3),6β-hydroxy-3-oxo-11,13(18)-oleanadien-28-oic acid(4),3-O-acetyloleanolic acid(5),3β-hydroxy-olean-18-ene-germanicol(6),corosolic acid(7),3β,6β-dihydroxy oleana-11,13(18)-dien-28-acid(8),uvaol(9),3β-hydroxy-oleana-11,13(18)-dien-28-oic acid(10),quercetin-3-O-α-L-rhamnoside(11),kaempferol-3-O-α-L-rhamnoside(12),protocatechuic aicd(13),vanillic acid(14),re-spectively.Conclusion:Among them,compounds 1 to 3 are isolated from Viburnum genus for the first time,compounds 4 to 6,12 to 14 are isolated from Viburnum taitoense for the first time.Compound 7 shows strong anti-inflammatory activity with IC50 value of(6.12±0.32)μmol/L,significantly better than the positive drug dexamethasone.Compounds 4,5,8 to 10 show moderate anti-inflammatory ac-tivities.关键词
台东荚蒾/化学成分/抗炎活性Key words
Viburnum taitoense Hayata/Chemical constituents/Anti-inflammatory activity分类
医药卫生引用本文复制引用
李博术,邹录惠,张寒翠,王璇,邱莉,谢集照..台东荚蒾化学成分及抗炎活性研究[J].中药材,2024,47(9):2233-2237,5.基金项目
广西自然科学基金项目(2023GXNSFAA026286) （2023GXNSFAA026286）
国家药品监督管理局中药材质量监测与评价重点实验室开放课题(KFKT2022-6) （KFKT2022-6）
