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中国南海桶状海绵Xestospongia sp.的化学成分及其生物活性研究

张子茹 曾艳波 许含 姚励功 郭跃伟 苏明智

中药材2024，Vol.47Issue(9)：2242-2249,8.
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中药材2024，Vol.47Issue(9)：2242-2249,8.DOI:10.13863/j.issn1001-4454.2024.09.018

中国南海桶状海绵Xestospongia sp.的化学成分及其生物活性研究

Chemical Constituents and Biological Activities of the Marine Sponge Xestospongia sp.from South China Sea

张子茹 1曾艳波 2许含 3姚励功 4郭跃伟 4苏明智4

作者信息

  • 1. 河北农业大学海洋学院,河北 秦皇岛 066005||烟台新药创制山东省实验室/中科环渤海(烟台)药物高等研究院,山东 烟台 264117||中国热带农业科学院热带生物技术研究所海南省海洋生物资源功能性成分研究与利用重点实验室,海南 海口 571101
  • 2. 河北农业大学海洋学院,河北 秦皇岛 066005||中国热带农业科学院热带生物技术研究所海南省海洋生物资源功能性成分研究与利用重点实验室,海南 海口 571101
  • 3. 烟台新药创制山东省实验室/中科环渤海(烟台)药物高等研究院,山东 烟台 264117||烟台大学药学院,山东 烟台 264005
  • 4. 烟台新药创制山东省实验室/中科环渤海(烟台)药物高等研究院,山东 烟台 264117
  • 折叠

摘要

Abstract

Objective:To study the chemical constituents and biological activities of the marine sponge Xestospongia sp.from South China Sea.Methods:The compounds were isolated and purified by silica gel,gel,semi-preparative high performance liquid chromatogra-phy and other chromatography methods.The structures of the compounds were identified by spectral data.Results:Nineteen compounds were isolated from the marine sponge Xestospongia sp.and identified as cholest-4-en-3-one(1),(22E)-3β-hydroxycholesta-5,22-dien-24-one(2),saringosterol(3),(3β,24R,28R)-24,28-epoxystigmast-5-en-3-ol(4),24-ketocholesterol(5),(7α)-7-hydroxy-4,24(28)-ergostadien-3-one(6),7-ketocholesterol(7),(22E)-cholesta-5,22-dien-3-ol(8),24-methylenecholesterol(9),β-sitosterol(10),ergos-ta-5,22-dien-3β-ol(11),cholesterol(12),spatosrerol(13),ergosta-6β-hydroxy-4,24(28)-dien-3-one(14),(3β,22E,24S)-3-hydroxy-ergosta-5,22-dien-7-one(15),7-ketositosterol(16),6β-hydroxycholest-4-en-3-one(17),thymidine(18),indazole(19),respectively.Conclusion:Among them,compounds 1,2,4,6,13 to 19 are isolated from the marine sponge Xestospongia sp.for the first time.Besides,compounds 2,4 to 7,14,15 show moderate anti-proliferation activity to human non-small cell lung cancer H-1299 cells,compounds 2,5 to 7 show moderate anti-proliferation activity to human non-small cell lung cancer HCC-827 cells,compounds 5 and 6 show moderate anti-proliferation activity to human non-small cell lung cancer A-549 cells,compounds 2,3,5 to 7 show significant antibacterial activity against Streptococcus parauberis SPOF3K,compound 9 shows significant antibacterial activity against human pathogen Vancomycin-resist-ant Enterococcus faecium G13.

关键词

桶状海绵/Xestospongia sp./甾体/抗肿瘤活性/耐药菌/抗菌活性

Key words

Marine sponge/Xestospongia sp./Steroid/Antitumor activity/Drug-resistant bacteria/Antibacterial activity

分类

医药卫生

引用本文复制引用

张子茹,曾艳波,许含,姚励功,郭跃伟,苏明智..中国南海桶状海绵Xestospongia sp.的化学成分及其生物活性研究[J].中药材,2024,47(9):2242-2249,8.

基金项目

国家自然科学基金资助项目(81991521) （81991521）

国家重点研发计划(2022YFC2804100) （2022YFC2804100）

山东省实验室项目(SYS202205) （SYS202205）

中药材

OA北大核心CSTPCD

1001-4454

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