肿瘤药学2025，Vol.15Issue(1)：38-45,8.DOI:10.3969/j.issn.2095-1264.2025.01.05
铁死亡在肿瘤免疫微环境中的双重角色:机遇与挑战并存
The dual roles of ferroptosis in the tumor immune microenvironment:both opportunities and challenges
摘要
Abstract
Ferroptosis,a form of regulated cell death induced by iron-dependent lipid peroxidation,has attracted exten-sive attention in the field of cancer therapy in recent years.While immunotherapy has emerged as a promising star in tumor treatment with progressive therapeutic achievements,it still faces clinical limitations.This review deeply discusses the dual roles of ferroptosis in shaping the tumor immune microenvironment and modulating anti-tumor immunity,analyzes its clini-cal application potential in tumor immunotherapy,and proposes a novel strategy to develop more effective and safer immu-notherapeutic approaches through ferroptosis regulation.关键词
铁死亡/肿瘤/免疫微环境/免疫治疗Key words
Ferroptosis/Cancer/Immune microenvironment/Immunotherapy分类
临床医学引用本文复制引用
方慧桧,张秀,洪婷,房超,蔡立,王瑛,吴娜怡园,王静..铁死亡在肿瘤免疫微环境中的双重角色:机遇与挑战并存[J].肿瘤药学,2025,15(1):38-45,8.基金项目
国家自然科学基金项目(82473222) （82473222）
湖南省自然科学基金部门联合基金(2024JJ8132) （2024JJ8132）
湖南省卫生健康委科研项目(B2023047708) （B2023047708）
湖南省肿瘤医院攀登计划科研项目(2023NSFC-A003). （2023NSFC-A003）
