肿瘤药学2025，Vol.15Issue(1)：53-58,6.DOI:10.3969/j.issn.2095-1264.2025.01.07
姜黄素通过抑制HR通路增强PEO1卵巢癌细胞系对尼拉帕利的敏感性
Curcumin enhances the sensitivity of PEO1 ovarian cancer cell line to niraparib by inhibiting the homologous recombination repair pathway
摘要
Abstract
Objective To investigate the effects and mechanisms of curcumin on the sensitivity of PEO1 ovarian cancer cell line to niraparib.Methods The effects of curcumin and niraparib combination treatment on PEO1 cell proliferation and apoptosis were assessed using CCK8 assay,colony formation assay,and TUNEL assay,respectively.The impact of curcum-in on the homologous recombination repair(HR)pathway and its mechanism were evaluated via RAD51 foci detection and Western blotting.Results The combination of curcumin with niraparib significantly inhibited PEO1 cell proliferation and promoted apoptosis.Curcumin enhanced the sensitivity of PEO1 cells to niraparib,accompanied by a marked reduction in RAD51 protein expression and suppression of HR pathway functionality.Conclusion Curcumin increased the sensitivity of PEO1 ovarian cancer cell line to niraparib by downregulating the RAD51 protein expression and inhibiting the HR path-way.关键词
卵巢癌/姜黄素/尼拉帕利/同源重组修复/RAD51Key words
Ovarian cancer/Curcumin/Niraparib/Homologous recombination repair/RAD51分类
临床医学引用本文复制引用
盛家佳,李贺,郑胜安,聂娟,周莹,李辉..姜黄素通过抑制HR通路增强PEO1卵巢癌细胞系对尼拉帕利的敏感性[J].肿瘤药学,2025,15(1):53-58,6.基金项目
国家自然科学基金青年项目(82303035). （82303035）
