局解手术学杂志2025，Vol.34Issue(4)：305-309,5.DOI:10.11659/jjssx.12E024094
双位点重复经颅磁刺激对主观耳鸣患者脑区功能改变的研究
Effect of dual-site repetitive transcranial magnetic stimulation on the changes of brain function in patients with subjective tinnitus
摘要
Abstract
Objective To detect the characteristics of whole-brain functional changes in patients with subjective tinnitus(ST)after"frontal-temporal"dual-site repetitive transcranial magnetic stimulation(rTMS)by resting-state functional magnetic resonance imaging(rs-fMRI).Methods A total of 45 ST patients were enrolled,and assessments of tinnitus severity and rs-fMRI scans were performed before and 2 weeks after treatment with"frontal-temporal"dual-site rTMS.Regional homogeneity(ReHo),fractional amplitude of low-frequency fluctuations(fALFF),degree centrality(DC)and seed-based functional connectivity(FC)were analyzed before and after treatment in ST patients.Results Tinnitus handicap inventory(THI)score of ST patients 2 weeks after treatment was significantly decreased compared with that before treatment(P<0.001).ReHo values of the right inferior parietal lobule decreased,fALFF values of the right temporal pole increased,fALFF values of the right superior temporal gyrus decreased,and DC(weighted)and DC(Binarized)values of the right medial temporal gyrus all decreased in ST patients 2 weeks after treatment compared with those before treatment(P<0.05,GRF correction).Using the above differential brain regions as seed points for FC analysis,FC values between right superior temporal gyrus(fALFF)and right middle temporal gyrus reduced,FC values between right middle temporal gyrus[(DC(weighted)]and right superior occipital gyrus reduced,and FC values between right middle temporal gyrus[DC(Binarized)]and right superior occipital gyrus reduced 2 weeks after treatment compared with those before treatment(P<0.05,GRF correction).Conclusion"Frontal-temporal"dual-site rTMS is initially effective for ST patients,and the auditory and non-auditory brain regions of ST patients showed different degrees of regional and interbrain function changes,mainly involving default mode network and visual-auditory network.关键词
重复经颅磁刺激/主观耳鸣/局部一致性/分数低频振幅/度中心度/静息状态功能磁共振成像Key words
repetitive transcranial magnetic stimulation/subjective tinnitus/regional homogeneity/fractional amplitude of low-frequency fluctuations/degree centrality/resting-state functional magnetic resonance imaging分类
医药卫生引用本文复制引用
荆国庆,文凤,余露,韩祺,武文婧,张杨..双位点重复经颅磁刺激对主观耳鸣患者脑区功能改变的研究[J].局解手术学杂志,2025,34(4):305-309,5.基金项目
重庆市自然科学基金面上项目(cstc2020jcyj-msxmX0072) （cstc2020jcyj-msxmX0072）
