肿瘤药学2025，Vol.15Issue(1)：81-89,9.DOI:10.3969/j.issn.2095-1264.2025.01.11
药物基因组学在抗肿瘤新药研发中的应用与展望
Application and prospect of pharmacogenomics in the development of novel anti-tumor drugs
李薇 1刘昭前1
作者信息
- 1. 中南大学湘雅医院 临床药理研究所/遗传药理学湖南省重点实验室,湖南 长沙,410078
- 折叠
摘要
Abstract
Pharmacogenomics has laid a critical foundation for the development of novel anti-tumor drugs and individu-alized precision therapy by identifying gene variants and targets related to drug response.In the development of anti-cancer drugs,the application of techniques such as genome-wide association studies and whole exome sequencing has provided important avenues for the identification of new drug targets.Genotypic stratification of patients makes the design of clinical trials of new drugs more accurate,not only shortening trial duration and reducing costs,but also improving the accuracy of clinical efficacy evaluation,thereby reducing the risk of drug development failure.Looking forward to the future,with the continuous progress of sequencing technology,pharmacogenomics based on multi-gene analysis will play an increasingly significant role in anti-tumor drug development.However,how to fully tap the potential of these technologies and strength-en the collaborative cooperation between clinical,scientific research and industry is still the core issue to be solved in the process of pharmacogenomics to help the development of anti-tumor drugs.关键词
药物基因组学/抗肿瘤新药研发/基因组学技术/个体化治疗/临床试验Key words
Pharmacogenomics/Development of novel anti-tumor drugs/Genomic technologies/Individualized treat-ment/Clinical trial分类
医药卫生引用本文复制引用
李薇,刘昭前..药物基因组学在抗肿瘤新药研发中的应用与展望[J].肿瘤药学,2025,15(1):81-89,9.
