中药材2024，Vol.47Issue(8)：1957-1965,9.DOI:10.13863/j.issn1001-4454.2024.08.015
桔梗中三萜皂苷类化学成分研究
Chemical Constituents of Triterpene Saponins from Platycodon grandiflorum
摘要
Abstract
Objective:To study the triterpenoid saponins from the roots of Platycodon grandiflorum.Methods:The triterpenoid sapo-nins of Platycodon grandiflorum were isolated and purified by reflux extraction,macroporous resin,silica gel column chromatography and preparative HPLC,the structures were identified by NMR and MS.The inflammatory model of mice macrophages(RAW264.7)induced by LPS was used to determine the anti-inflammatory effects of the compounds.Results:Nineteen triterpenoid saponins were isolated from the 75%ethanol extract of Platycodon grandiflorum and identified as ursolic acid(1),betulin aldehyde(2),betulin(3),28-O-lauryl-betulin(4),β-D-glucopyranosyl-2α,3β,23-trihydroxyolean-12-en-28-oate(5),3-O-β-D-glucuronopyranosyl methyl ester-28-O-β-D-glu-copyranoside(6),lupeol(7),platycodonoid B(8),platyconic acid B lactone(9),deapio-platycodin D(10),3″-O-acetylplatycodin-D(11),3″-O-acetylplatycodin-D2(12),deapio-platycoside E(13),platycodin E(14),polygalacin D(15),3″-O-acetylpolygalacin-D(16),polygalacin D2(17),3″-O-acetylpolygalacin-D2(18),platycoside G3(19),respectively.Conclusion:Among them,compounds 1 to 6 are isolated from Platycodonaceae for the first time,compound 7 is isolated from Platycodon grandiflorum for the first time.Except for compounds 1 and 3,other compounds show significant anti-inflammatory activities.关键词
桔梗/三萜皂苷/化学成分/抗炎活性Key words
Platycodon grandiflorum(Jacq.)A.DC./Triterpene saponins/Chemical constituents/Anti-inflammatory activity分类
医药卫生引用本文复制引用
刘艳,王宇瑄,刘培,潘娟,管伟,匡海学,杨炳友..桔梗中三萜皂苷类化学成分研究[J].中药材,2024,47(8):1957-1965,9.基金项目
黑龙江省重点研发计划项目(GA21D008) （GA21D008）
黑龙江省"头雁"团队([2019]5号) （[2019]5号）
黑龙江省"双一流"学科协同创新成果建设项目(LJGXCG2022-096) （LJGXCG2022-096）
